MeSH Browser

MeSH Heading: Immunoglobulin alpha-Chains
Tree Number(s): D12.776.124.486.485.114.619.026.515; D12.776.124.486.485.705.500.350; D12.776.124.790.651.114.619.026.515; D12.776.124.790.651.705.500.350; D12.776.377.715.548.114.619.026.515; D12.776.377.715.548.705.500.350
Unique ID: D007137
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007137
Annotation: gammopathy: coordinate IMMUNOGLOBULIN ALPHA-CHAINS (IM) with PARAPROTEINEMIAS (IM) but consider also HYPERGAMMAGLOBULINEMIA (IM) or ALPHA-CHAIN DISEASE (IM), follow text; DF: IG ALPHA CHAIN
Scope Note: The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.
Entry Version: IG ALPHA CHAINS
Entry Term(s): Ig alpha Chains; Immunoglobulin alpha-Chain; Immunoglobulins, alpha-Chain; alpha-Chain Immunoglobulins; alpha-Immunoglobulin Heavy Chain; alpha-Immunoglobulin Heavy Chains
Pharm Action: Immunologic Factors
Registry Numbers: 0
Previous Indexing: IgA (1973-1975); Immunoglobulin Fragments (1973-1975); Immunoglobulins, Heavy Chain (1975)
Public MeSH Note: 2006; see IMMUNOGLOBULINS, ALPHA-CHAIN 1992-2005, see IMMUNOGLOBULINS, ALPHA CHAIN 1991, see IMMUNOGLOBULINS, HEAVY CHAIN 1976-1990
History Note: 2006 (1976)
Date Established: 1991/01/01
Date of Entry: 1975/07/18
Revision Date: 2019/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Antibodies [D12.776.124.486.485.114]
        
        Immunoglobulin Isotypes [D12.776.124.486.485.114.619]
        
        Immunoglobulin A [D12.776.124.486.485.114.619.026]
        
        Immunoglobulin A, Secretory [D12.776.124.486.485.114.619.026.030]
        
        Immunoglobulin alpha-Chains [D12.776.124.486.485.114.619.026.515]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Immunoglobulin Subunits [D12.776.124.486.485.705]
        
        Immunoglobulin Heavy Chains [D12.776.124.486.485.705.500]
        
        Immunoglobulin alpha-Chains [D12.776.124.486.485.705.500.350]
        
        Immunoglobulin delta-Chains [D12.776.124.486.485.705.500.360]
        
        Immunoglobulin epsilon-Chains [D12.776.124.486.485.705.500.370]
        
        Immunoglobulin gamma-Chains [D12.776.124.486.485.705.500.380]
        
        Immunoglobulin mu-Chains [D12.776.124.486.485.705.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Antibodies [D12.776.124.790.651.114]
        
        Immunoglobulin Isotypes [D12.776.124.790.651.114.619]
        
        Immunoglobulin A [D12.776.124.790.651.114.619.026]
        
        Immunoglobulin A, Secretory [D12.776.124.790.651.114.619.026.030]
        
        Immunoglobulin alpha-Chains [D12.776.124.790.651.114.619.026.515]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Immunoglobulin Subunits [D12.776.124.790.651.705]
        
        Immunoglobulin Heavy Chains [D12.776.124.790.651.705.500]
        
        Immunoglobulin alpha-Chains [D12.776.124.790.651.705.500.350]
        
        Immunoglobulin delta-Chains [D12.776.124.790.651.705.500.360]
        
        Immunoglobulin epsilon-Chains [D12.776.124.790.651.705.500.370]
        
        Immunoglobulin gamma-Chains [D12.776.124.790.651.705.500.380]
        
        Immunoglobulin mu-Chains [D12.776.124.790.651.705.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Antibodies [D12.776.377.715.548.114]
        
        Immunoglobulin Isotypes [D12.776.377.715.548.114.619]
        
        Immunoglobulin A [D12.776.377.715.548.114.619.026]
        
        Immunoglobulin A, Secretory [D12.776.377.715.548.114.619.026.030]
        
        Immunoglobulin alpha-Chains [D12.776.377.715.548.114.619.026.515]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Immunoglobulin Subunits [D12.776.377.715.548.705]
        
        Immunoglobulin Heavy Chains [D12.776.377.715.548.705.500]
        
        Immunoglobulin alpha-Chains [D12.776.377.715.548.705.500.350]
        
        Immunoglobulin delta-Chains [D12.776.377.715.548.705.500.360]
        
        Immunoglobulin epsilon-Chains [D12.776.377.715.548.705.500.370]
        
        Immunoglobulin gamma-Chains [D12.776.377.715.548.705.500.380]
        
        Immunoglobulin mu-Chains [D12.776.377.715.548.705.500.500]

Immunoglobulin alpha-Chains Preferred

Concept UI: M0011123
Registry Numbers: 0
Scope Note: The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.
Terms: Immunoglobulin alpha-Chains Preferred Term
Term UI T633990
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006); alpha-Chain Immunoglobulins
Term UI T021371
Date01/01/1986
LexicalTag NON
ThesaurusID UNK (19XX); Ig alpha Chains
Term UI T000952296
Date03/01/2019
LexicalTag NON
ThesaurusID NLM (2020); alpha-Immunoglobulin Heavy Chains
Term UI T633998
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006); Immunoglobulin alpha-Chain
Term UI T634005
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006); Immunoglobulins, alpha-Chain
Term UI T021372
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1976); alpha-Immunoglobulin Heavy Chain
Term UI T633997
Date03/22/2005
LexicalTag NON
ThesaurusID NLM (2006)

Immunoglobulin alpha-Chains MeSH Descriptor Data 2025