MeSH Browser

MeSH Heading: Darier Disease
Tree Number(s): C16.320.850.190; C17.800.428.275; C17.800.827.190
Unique ID: D007644
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007644
Scope Note: An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.
Entry Version: DARIER DIS
Entry Term(s): Acantholytic Dyskeratotic Epidermal Nevi; Acantholytic Dyskeratotic Epidermal Nevus; Acrokeratosis Verruciformis; Acrokeratosis Verruciformis of Hopf; Darier's Disease; Darier-White Disease; Hopf Disease; Keratosis Follicularis
Public MeSH Note: 2009; see KERATOSIS FOLLICULARIS 1966-2008
History Note: 2009 (1966)
Date Established: 2009/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/18

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0011973
Scope Note: An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.
Terms: Darier Disease Preferred Term
Term UI T022959
Date06/15/1984
LexicalTag EPO
ThesaurusID; Darier's Disease
Term UI T022960
Date03/30/1974
LexicalTag EPO
ThesaurusID; Keratosis Follicularis
Term UI T022961
Date01/01/1999
LexicalTag NON
ThesaurusID; Darier-White Disease
Term UI T705200
Date09/04/2007
LexicalTag ACX
ThesaurusID

Darier Disease MeSH Descriptor Data 2023