MeSH Browser

MeSH Heading: Gerstmann-Straussler-Scheinker Disease
Tree Number(s): C01.207.800.350; C10.228.228.800.350; C10.574.500.425; C10.574.843.400; C16.320.400.350
Unique ID: D016098
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016098
Annotation: a prion dis: do not confuse with GERSTMANN SYNDROME, a type of agnosia
Scope Note: An autosomal dominant familial prion disease with a wide spectrum of clinical presentations including ATAXIA, spastic paraparesis, extrapyramidal signs, and DEMENTIA. Clinical onset is in the third to sixth decade of life and the mean duration of illness prior to death is five years. Several kindreds with variable clinical and pathologic features have been described. Pathologic features include cerebral prion protein amyloidosis, and spongiform or neurofibrillary degeneration. (From Brain Pathol 1998 Jul;8(3):499-513; Brain Pathol 1995 Jan;5(1):61-75)
Entry Version: GERSTMANN STRAUSSLER SCHEINKER DIS
Entry Term(s): Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type; Gerstmann-Straussler Disease; Gerstmann-Straussler Inherited Spongiform Encephalopathy; Gerstmann-Straussler Syndrome; Gerstmann-Straussler-Scheinker Syndrome; Inherited Spongiform Encephalopathy, Gerstmann-Straussler
Previous Indexing: Slow Virus Diseases (1988-1990)
Public MeSH Note: 2000; see GERSTMANN-STRAUSSLER SYNDROME 1991-1999; see SLOW VIRUS DISEASES 1988-1990; GERSTMANN-STRAUSSLER-SCHEINKER DISEASE was GERSTMANN-STRAUSSLER-SCHEINDER DISEASE see GERSTMANN-STRAUSSLER SYNDROME 1991
History Note: 2000(1991); use SLOW VIRUS DISEASES 1988-1990; GERSTMANN-STRAUSSLER-SCHEINKER DISEASE was GERSTMANN-STRAUSSLER-SCHEINDER DISEASE see GERSTMANN-STRAUSSLER SYNDROME 1991
Date Established: 1991/01/01
Date of Entry: 1990/06/06
Revision Date: 2019/06/17

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

transmission (TM)

urine (UR)

veterinary (VE)

virology (VI)

Infections [C01]
- Central Nervous System Infections [C01.207]
  - Prion Diseases [C01.207.800]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Central Nervous System Infections [C10.228.228]
    - Prion Diseases [C10.228.228.800]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Prion Diseases [C10.574.843]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]

Gerstmann-Straussler-Scheinker Disease Preferred

Concept UI: M0024593
Scope Note: An autosomal dominant familial prion disease with a wide spectrum of clinical presentations including ATAXIA, spastic paraparesis, extrapyramidal signs, and DEMENTIA. Clinical onset is in the third to sixth decade of life and the mean duration of illness prior to death is five years. Several kindreds with variable clinical and pathologic features have been described. Pathologic features include cerebral prion protein amyloidosis, and spongiform or neurofibrillary degeneration. (From Brain Pathol 1998 Jul;8(3):499-513; Brain Pathol 1995 Jan;5(1):61-75)
Terms: Gerstmann-Straussler-Scheinker Disease Preferred Term
Term UI T047840
Date12/11/1989
LexicalTag EPO
ThesaurusID; Gerstmann-Straussler Inherited Spongiform Encephalopathy
Term UI T368339
Date11/05/1999
LexicalTag EPO
ThesaurusID NLM (2000); Gerstmann-Straussler Syndrome
Term UI T047839
Date01/01/1999
LexicalTag EPO
ThesaurusID NLM (1991); Gerstmann-Straussler-Scheinker Syndrome
Term UI T751207
Date05/14/2009
LexicalTag EPO
ThesaurusID; Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type
Term UI T751208
Date05/14/2009
LexicalTag EPO
ThesaurusID; Gerstmann-Straussler Disease
Term UI T811555
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Inherited Spongiform Encephalopathy, Gerstmann-Straussler
Term UI T368340
Date11/05/1999
LexicalTag EPO
ThesaurusID NLM (2000)

Gerstmann-Straussler-Scheinker Disease MeSH Descriptor Data 2025