MeSH Browser

MeSH Heading: Lafora Disease
Tree Number(s): C10.228.140.490.375.130.650.500; C10.228.140.490.493.063.650.500; C10.574.500.529; C16.320.400.480
Unique ID: D020192
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020192
Scope Note: A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).
Entry Version: LAFORA DIS
Entry Term(s): Epilepsy Progressive Myoclonic 2; Epilepsy, Progressive Myoclonic 2A; Epilepsy, Progressive Myoclonic, Lafora; Lafora Body Disease; Lafora Body Disease, Late Onset; Lafora Body Disorder; Lafora Progressive Myoclonic Epilepsy; Lafora Progressive Myoclonus Epilepsy; Lafora Type Progressive Myoclonic Epilepsy; Lafora-Body Disease, Late Onset; Late Onset Lafora Body Disease; Myoclonic Epilepsy of Lafora; Progressive Myoclonic Epilepsy Type 2; Progressive Myoclonic Epilepsy, Lafora; Progressive Myoclonic Epilepsy, Lafora Type; Progressive Myoclonus Epilepsy, Lafora Type
Previous Indexing: Epilepsies, Myoclonic (1977-1999); Epilepsy (1966-1976)
Public MeSH Note: 2000; see Epilepsy, Myoclonic 1977-1999
History Note: 2000; use Epilepsy, Myoclonic 1977-1999
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2017/02/24

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Epilepsy [C10.228.140.490]
      - Epilepsy, Generalized [C10.228.140.490.375]
        
        Epilepsies, Myoclonic [C10.228.140.490.375.130]
        
        Myoclonic Epilepsies, Progressive [C10.228.140.490.375.130.650]
        
        Lafora Disease [C10.228.140.490.375.130.650.500]
        
        MERRF Syndrome [C10.228.140.490.375.130.650.700]
        
        Unverricht-Lundborg Syndrome [C10.228.140.490.375.130.650.900]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Epilepsy [C10.228.140.490]
      - Epileptic Syndromes [C10.228.140.490.493]
        
        Epilepsies, Myoclonic [C10.228.140.490.493.063]
        
        Myoclonic Epilepsies, Progressive [C10.228.140.490.493.063.650]
        
        Lafora Disease [C10.228.140.490.493.063.650.500]
        
        MERRF Syndrome [C10.228.140.490.493.063.650.700]
        
        Unverricht-Lundborg Syndrome [C10.228.140.490.493.063.650.900]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]

Lafora Disease Preferred

Concept UI: M0328685
Scope Note: A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).
Terms: Lafora Disease Preferred Term
Term UI T014727
Date04/26/1976
LexicalTag EPO
ThesaurusID; Epilepsy, Progressive Myoclonic, Lafora
Term UI T368853
Date10/12/1999
LexicalTag EPO
ThesaurusID; Progressive Myoclonic Epilepsy, Lafora Type
Term UI T368854
Date10/12/1999
LexicalTag EPO
ThesaurusID NLM (2000); Lafora Body Disease
Term UI T368855
Date10/12/1999
LexicalTag EPO
ThesaurusID; Lafora Progressive Myoclonic Epilepsy
Term UI T368856
Date10/12/1999
LexicalTag EPO
ThesaurusID; Lafora Type Progressive Myoclonic Epilepsy
Term UI T368857
Date10/12/1999
LexicalTag EPO
ThesaurusID; Progressive Myoclonic Epilepsy, Lafora
Term UI T368858
Date10/12/1999
LexicalTag EPO
ThesaurusID NLM (2000); Lafora Body Disorder
Term UI T764287
Date01/15/2010
LexicalTag EPO
ThesaurusID; Myoclonic Epilepsy of Lafora
Term UI T764288
Date01/15/2010
LexicalTag EPO
ThesaurusID; Epilepsy Progressive Myoclonic 2
Term UI T764289
Date01/15/2010
LexicalTag NON
ThesaurusID; Lafora Progressive Myoclonus Epilepsy
Term UI T841858
Date04/18/2013
LexicalTag EPO
ThesaurusID GHR (2014); Progressive Myoclonic Epilepsy Type 2
Term UI T841859
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Progressive Myoclonus Epilepsy, Lafora Type
Term UI T841860
Date04/18/2013
LexicalTag EPO
ThesaurusID GHR (2014); Epilepsy, Progressive Myoclonic 2A
Term UI T845653
Date06/14/2013
LexicalTag NON
ThesaurusID OMIM (2013)

Lafora Body Disease, Late Onset Narrower

Lafora Disease MeSH Descriptor Data 2025