MeSH Browser

MeSH Heading: F-Box Proteins
Tree Number(s): D12.776.157.169
Unique ID: D044783
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D044783
Scope Note: A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in the process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.
Entry Term(s): F-Box Domain Protein; F-Box Protein; F-Box Protein Family
See Also: F-Box Motifs
Public MeSH Note: 2004
History Note: 2004
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0446216
Scope Note: A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in the process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.
Terms: F-Box Proteins Preferred Term
Term UI T533996
Date02/27/2003
LexicalTag NON
ThesaurusID NLM (2004); F-Box Protein
Term UI T001007232
Date02/10/2020
LexicalTag NON
ThesaurusID NLM (2021); F-Box Protein Family
Term UI T533997
Date02/27/2003
LexicalTag NON
ThesaurusID NLM (2004); F-Box Domain Protein
Term UI T540699
Date05/14/2003
LexicalTag NON
ThesaurusID NLM (2004)

F-Box Proteins MeSH Descriptor Data 2025