MeSH Browser

MeSH Heading: Protein Tyrosine Phosphatase, Non-Receptor Type 2
Tree Number(s): D08.811.277.352.650.775.300.200; D12.776.476.564.300.200
Unique ID: D054578
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054578
Scope Note: A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative splicing of the mRNA for this phosphatase results in the production at two gene products, one of which includes a C-terminal nuclear localization domain that may be involved in the transport of the protein to the CELL NUCLEUS. Although initially referred to as T-cell protein tyrosine phosphatase the expression of this subtype occurs widely.
Entry Term(s): Protein Tyrosine Phosphatase, Non-Receptor Type 2, TC45 Isoform; Protein Tyrosine Phosphatase, Non-Receptor Type 2, TC48 Isoform; T-Cell Protein Tyrosine Phosphatase; TC-PTP; TC45 Enzyme; TC45 Protein Tyrosine Phosphatase; TC48 Enzyme; TC48 Protein Tyrosine Phosphatase; TCPTP Enzyme
Related Numbers: EC 3.1.3.48
Public MeSH Note: 2008; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2 was indexed under PROTEIN TYROSINE PHOSPHATASE 1994-2007
History Note: 2008(1994)
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0228158
Related Numbers: EC 3.1.3.48
Scope Note: A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1. Alternative splicing of the mRNA for this phosphatase results in the production at two gene products, one of which includes a C-terminal nuclear localization domain that may be involved in the transport of the protein to the CELL NUCLEUS. Although initially referred to as T-cell protein tyrosine phosphatase the expression of this subtype occurs widely.
Terms: Protein Tyrosine Phosphatase, Non-Receptor Type 2 Preferred Term
Term UI T690209
Date01/26/2007
LexicalTag NON
ThesaurusID NLM (2008); TC-PTP
Term UI T258162
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (2008); T-Cell Protein Tyrosine Phosphatase
Term UI T258163
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); TCPTP Enzyme
Term UI T372623
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008)

Protein Tyrosine Phosphatase, Non-Receptor Type 2 MeSH Descriptor Data 2025