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Protein Tyrosine Phosphatase, Non-Receptor Type 22 MeSH Descriptor Data 2023


MeSH Heading
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Tree Number(s)
D08.811.277.352.650.775.300.930
D12.776.476.564.300.930
Unique ID
D054596
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054596
Scope Note
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
Entry Term(s)
Lymphoid Phosphatase
Lyp1 PTPase
Lyp2 PTPase
PTPN-22 Protein
PTPase Lyp
Protein-Tyrosine Phosphatase Lyp
Tyrosine Protein Phosphatase, Non-Receptor Type 22
Registry Number
EC 3.1.3.48
Related Numbers
EC 3.1.3.48
Public MeSH Note
2008; TYROSINE PROTEIN PROSPHATASE, NON-RECEPTOR TYPE 22 was indexed under PROTEIN TYROSINE PHOSPHATASES 1999-2007
History Note
2008(1999)
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Protein Tyrosine Phosphatase, Non-Receptor Type 22 Preferred
Lyp1 PTPase Narrower
Lyp2 PTPase Narrower
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