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Protein Tyrosine Phosphatase, Non-Receptor Type 12 MeSH Descriptor Data 2023


MeSH Heading
Protein Tyrosine Phosphatase, Non-Receptor Type 12
Tree Number(s)
D08.811.277.352.650.775.300.850
D12.776.476.564.300.850
Unique ID
D054594
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054594
Scope Note
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
Entry Term(s)
PEP PTPase
PEP Protein Tyrosine Phosphatase
PEST-Enriched Phosphatase
PTP-PEST
Registry Number
EC 3.1.3.48
Public MeSH Note
2008; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 12 was indexed under PROTEIN TYROSINE PHOSPHATASE 1994-2007
History Note
2008(1994)
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Protein Tyrosine Phosphatase, Non-Receptor Type 12 Preferred
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