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Cyclic Nucleotide Phosphodiesterases, Type 1 MeSH Descriptor Data 2023


MeSH Heading
Cyclic Nucleotide Phosphodiesterases, Type 1
Tree Number(s)
D08.811.277.352.640.150.100
D08.811.277.352.640.155.100
D12.776.476.008.100
D12.776.476.009.100
Unique ID
D054677
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054677
Scope Note
A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.
Entry Term(s)
Ca(2+)-CaM-Stimulated PDE
Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase
Ca-CaM-Phosphodiesterase
Calcium-Calmodulin-Dependent Phosphodiesterase
Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase
Calmodulin Phosphodiesterase
Calmodulin-Dependent Phosphodiesterase
Calmodulin-Dependent cGMP Phosphodiesterase
Cyclic Nucleotide Phosphodiesterase PDE1 Family
Cyclic Nucleotide Phosphodiesterases, Type 1A
Cyclic Nucleotide Phosphodiesterases, Type 1B
Cyclic Nucleotide Phosphodiesterases, Type 1C
Cyclic Nucleotide Phosphodiesterases, Type I
PDE1 Phosphodiesterases
Phosphodiesterase 1A, Calmodulin-Dependent
Phosphodiesterase 1B, Calmodulin-Dependent
Phosphodiesterase 1C, Calmodulin-Dependent
Registry Number
EC 3.1.4.17
Related Numbers
EC 3.1.4.17
EC 3.1.4.35
Previous Indexing
3',5'-Cyclic-GMP Phosphodiesterases (1981-2007)
Public MeSH Note
2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE I was indexed under PHOSPHORIC DIESTER HYDROLASES 1990-2007, for CA++ CALMODULIN DEPENDENT CYCLIC AMP PHOSPHODIESTERASE see 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1986-2007, for CALMODULIN PHOSPHODIESTERASE see 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007, for CALMODULIN-DEPENDENT PHOSPHODIESTERASE see 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1984-2007
History Note
2008(1981) for CA++ CALMODULIN DEPENDENT CYCLIC AMP PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1986-2007, for CALMODULIN PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007, for CALMODULIN-DEPENDENT PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1984-2007
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Cyclic Nucleotide Phosphodiesterases, Type 1 Preferred
Cyclic Nucleotide Phosphodiesterases, Type 1B Narrower
Cyclic Nucleotide Phosphodiesterases, Type 1C Narrower
Cyclic Nucleotide Phosphodiesterases, Type 1A Narrower
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