MeSH Browser

MeSH Heading: Cyclic Nucleotide Phosphodiesterases, Type 1
Tree Number(s): D08.811.277.352.640.150.100; D08.811.277.352.640.155.100; D12.776.476.008.100; D12.776.476.009.100
Unique ID: D054677
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054677
Scope Note: A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.
Entry Term(s): Ca(2+)-CaM-Stimulated PDE; Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase; Ca-CaM-Phosphodiesterase; Calcium-Calmodulin-Dependent Phosphodiesterase; Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase; Calmodulin Phosphodiesterase; Calmodulin-Dependent Phosphodiesterase; Calmodulin-Dependent cGMP Phosphodiesterase; Cyclic Nucleotide Phosphodiesterase PDE1 Family; Cyclic Nucleotide Phosphodiesterases, Type 1A; Cyclic Nucleotide Phosphodiesterases, Type 1B; Cyclic Nucleotide Phosphodiesterases, Type 1C; Cyclic Nucleotide Phosphodiesterases, Type I; PDE1 Phosphodiesterases; Phosphodiesterase 1A, Calmodulin-Dependent; Phosphodiesterase 1B, Calmodulin-Dependent; Phosphodiesterase 1C, Calmodulin-Dependent
Related Numbers: EC 3.1.4.17; EC 3.1.4.35
Previous Indexing: 3',5'-Cyclic-GMP Phosphodiesterases (1981-2007)
Public MeSH Note: 2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE I was indexed under PHOSPHORIC DIESTER HYDROLASES 1990-2007, for CA++ CALMODULIN DEPENDENT CYCLIC AMP PHOSPHODIESTERASE see 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1986-2007, for CALMODULIN PHOSPHODIESTERASE see 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007, for CALMODULIN-DEPENDENT PHOSPHODIESTERASE see 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1984-2007
History Note: 2008(1981) for CA++ CALMODULIN DEPENDENT CYCLIC AMP PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1986-2007, for CALMODULIN PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007, for CALMODULIN-DEPENDENT PHOSPHODIESTERASE use 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1984-2007
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Diester Hydrolases [D08.811.277.352.640]
        
        3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
        
        Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.150.100]
        
        Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.150.200]
        
        Cyclic Nucleotide Phosphodiesterases, Type 3 [D08.811.277.352.640.150.300]
        
        Cyclic Nucleotide Phosphodiesterases, Type 4 [D08.811.277.352.640.150.400]
        
        Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.150.500]
        
        Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.150.600]
        
        Cyclic Nucleotide Phosphodiesterases, Type 7 [D08.811.277.352.640.150.700]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Diester Hydrolases [D08.811.277.352.640]
        
        3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
        
        Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.155.100]
        
        Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.155.200]
        
        Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.155.500]
        
        Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.155.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]

Cyclic Nucleotide Phosphodiesterases, Type 1 Preferred

Concept UI: M0177000
Related Numbers: EC 3.1.4.17; EC 3.1.4.35
Scope Note: A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.
Terms: Cyclic Nucleotide Phosphodiesterases, Type 1 Preferred Term
Term UI T692404
Date02/27/2007
LexicalTag NON
ThesaurusID NLM (2008); Ca(2+)-CaM-Stimulated PDE
Term UI T266067
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008); Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase
Term UI T266074
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008); Cyclic Nucleotide Phosphodiesterases, Type I
Term UI T691893
Date02/20/2007
LexicalTag NON
ThesaurusID NLM (2008); PDE1 Phosphodiesterases
Term UI T691894
Date02/20/2007
LexicalTag ABX
ThesaurusID NLM (2008); Cyclic Nucleotide Phosphodiesterase PDE1 Family
Term UI T691895
Date02/20/2007
LexicalTag ABX
ThesaurusID NLM (2008); Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase
Term UI T044113
Date06/28/1985
LexicalTag NON
ThesaurusID UNK (19XX); Calmodulin Phosphodiesterase
Term UI T044114
Date08/01/1980
LexicalTag NON
ThesaurusID UNK (19XX); Calmodulin-Dependent Phosphodiesterase
Term UI T044115
Date06/29/1983
LexicalTag NON
ThesaurusID UNK (19XX); Ca-CaM-Phosphodiesterase
Term UI T207003
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008); Calcium-Calmodulin-Dependent Phosphodiesterase
Term UI T207005
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Calmodulin-Dependent cGMP Phosphodiesterase
Term UI T207004
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2008)

Cyclic Nucleotide Phosphodiesterases, Type 1A Narrower

Cyclic Nucleotide Phosphodiesterases, Type 1B Narrower

Cyclic Nucleotide Phosphodiesterases, Type 1C Narrower

Cyclic Nucleotide Phosphodiesterases, Type 1 MeSH Descriptor Data 2025