MeSH Browser

MeSH Heading: Cyclic Nucleotide Phosphodiesterases, Type 4
Tree Number(s): D08.811.277.352.640.150.400; D12.776.476.008.400
Unique ID: D054703
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054703
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
Entry Term(s): Cyclic Nucleotide Phosphodiesterase PDE4 Family; Cyclic Nucleotide Phosphodiesterases, Type 4A; Cyclic Nucleotide Phosphodiesterases, Type 4A5; Cyclic Nucleotide Phosphodiesterases, Type 4B; Cyclic Nucleotide Phosphodiesterases, Type 4C; Cyclic Nucleotide Phosphodiesterases, Type 4D; Cyclic Nucleotide Phosphodiesterases, Type 4D3; PDE4 Phosphodiesterases; PDE4D3 Phosphodiesterase; Phosphodiesterase 4; Phosphodiesterase 4A; Phosphodiesterase 4B; Phosphodiesterase 4C; Phosphodiesterase 4D; Phosphodiesterase IV; Phosphodiesterase-4; Type 4 Cyclic Nucleotide Phosphodiesterase; cAMP-Specific Phosphodiesterase 4A5
Related Numbers: EC 3.1.4.17
Public MeSH Note: 2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007; CAMP-SPECIFIC PHOSPHODIESTERASE 4A5 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 2000-2007; PDE4D3 PHOSPHODIESTERASE was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1996-2007
History Note: 2008(1981)
Entry Combination: antagonists & inhibitors:Phosphodiesterase 4 Inhibitors
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Entry Combination: antagonists & inhibitors:Phosphodiesterase 4 Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Diester Hydrolases [D08.811.277.352.640]
        
        3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
        
        Cyclic Nucleotide Phosphodiesterases, Type 1 [D08.811.277.352.640.150.100]
        
        Cyclic Nucleotide Phosphodiesterases, Type 2 [D08.811.277.352.640.150.200]
        
        Cyclic Nucleotide Phosphodiesterases, Type 3 [D08.811.277.352.640.150.300]
        
        Cyclic Nucleotide Phosphodiesterases, Type 4 [D08.811.277.352.640.150.400]
        
        Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.150.500]
        
        Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.150.600]
        
        Cyclic Nucleotide Phosphodiesterases, Type 7 [D08.811.277.352.640.150.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]

Cyclic Nucleotide Phosphodiesterases, Type 4 Preferred

Concept UI: M0096215
Related Numbers: EC 3.1.4.17
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
Terms: Cyclic Nucleotide Phosphodiesterases, Type 4 Preferred Term
Term UI T692120
Date02/22/2007
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase IV
Term UI T126219
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Type 4 Cyclic Nucleotide Phosphodiesterase
Term UI T487805
Date03/27/2002
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase-4
Term UI T126218
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Cyclic Nucleotide Phosphodiesterase PDE4 Family
Term UI T692122
Date02/22/2007
LexicalTag NON
ThesaurusID NLM (2008); PDE4 Phosphodiesterases
Term UI T692123
Date02/22/2007
LexicalTag ABX
ThesaurusID NLM (2008); Phosphodiesterase 4
Term UI T126215
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008)

Cyclic Nucleotide Phosphodiesterases, Type 4C Narrower

Cyclic Nucleotide Phosphodiesterases, Type 4A Narrower

Cyclic Nucleotide Phosphodiesterases, Type 4A5 Narrower

Cyclic Nucleotide Phosphodiesterases, Type 4B Narrower

Cyclic Nucleotide Phosphodiesterases, Type 4D Narrower

Cyclic Nucleotide Phosphodiesterases, Type 4D3 Narrower

Cyclic Nucleotide Phosphodiesterases, Type 4 MeSH Descriptor Data 2025