NLM Logo

Cyclic Nucleotide Phosphodiesterases, Type 4 MeSH Descriptor Data 2023


MeSH Heading
Cyclic Nucleotide Phosphodiesterases, Type 4
Tree Number(s)
D08.811.277.352.640.150.400
D12.776.476.008.400
Unique ID
D054703
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054703
Scope Note
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
Entry Term(s)
Cyclic Nucleotide Phosphodiesterase PDE4 Family
Cyclic Nucleotide Phosphodiesterases, Type 4A
Cyclic Nucleotide Phosphodiesterases, Type 4A5
Cyclic Nucleotide Phosphodiesterases, Type 4B
Cyclic Nucleotide Phosphodiesterases, Type 4C
Cyclic Nucleotide Phosphodiesterases, Type 4D
Cyclic Nucleotide Phosphodiesterases, Type 4D3
PDE4 Phosphodiesterases
PDE4D3 Phosphodiesterase
Phosphodiesterase 4
Phosphodiesterase 4A
Phosphodiesterase 4B
Phosphodiesterase 4C
Phosphodiesterase 4D
Phosphodiesterase IV
Phosphodiesterase-4
Type 4 Cyclic Nucleotide Phosphodiesterase
cAMP-Specific Phosphodiesterase 4A5
Registry Number
EC 3.1.4.17
Related Numbers
EC 3.1.4.17
Public MeSH Note
2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007; CAMP-SPECIFIC PHOSPHODIESTERASE 4A5 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 2000-2007; PDE4D3 PHOSPHODIESTERASE was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1996-2007
History Note
2008(1981)
Entry Combination
antagonists & inhibitors:Phosphodiesterase 4 Inhibitors
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Cyclic Nucleotide Phosphodiesterases, Type 4 Preferred
Cyclic Nucleotide Phosphodiesterases, Type 4A5 Narrower
Cyclic Nucleotide Phosphodiesterases, Type 4D3 Narrower
Cyclic Nucleotide Phosphodiesterases, Type 4C Narrower
Cyclic Nucleotide Phosphodiesterases, Type 4D Narrower
Cyclic Nucleotide Phosphodiesterases, Type 4A Narrower
Cyclic Nucleotide Phosphodiesterases, Type 4B Narrower
page delivered in 0.156s