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Cyclic Nucleotide Phosphodiesterases, Type 3 MeSH Descriptor Data 2022


MeSH Heading
Cyclic Nucleotide Phosphodiesterases, Type 3
Tree Number(s)
D08.811.277.352.640.150.300
D12.776.476.008.300
Unique ID
D054684
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054684
Scope Note
A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
Entry Term(s)
Cyclic Nucleotide Phosphodiesterase PDE3 Family
Cyclic Nucleotide Phosphodiesterases, Type 3A
Cyclic Nucleotide Phosphodiesterases, Type 3B
Phosphodiesterase 3A
Phosphodiesterase 3B
Phosphodiesterase III
cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
cGMP-Inhibited Phosphodiesterase
Registry Number
EC 3.1.4.17
Related Numbers
EC 3.1.4.17
Public MeSH Note
2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1995-2007
History Note
2008(1995)
Entry Combination
antagonists & inhibitors:Phosphodiesterase 3 Inhibitors
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Cyclic Nucleotide Phosphodiesterases, Type 3 Preferred
Cyclic Nucleotide Phosphodiesterases, Type 3B Narrower
Cyclic Nucleotide Phosphodiesterases, Type 3A Narrower
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