MeSH Browser

MeSH Heading: Cyclic Nucleotide Phosphodiesterases, Type 3
Tree Number(s): D08.811.277.352.640.150.300; D12.776.476.008.300
Unique ID: D054684
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054684
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
Entry Term(s): Cyclic Nucleotide Phosphodiesterase PDE3 Family; Cyclic Nucleotide Phosphodiesterases, Type 3A; Cyclic Nucleotide Phosphodiesterases, Type 3B; Phosphodiesterase 3A; Phosphodiesterase 3B; Phosphodiesterase III; cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase; cGMP-Inhibited Phosphodiesterase
Registry Number: EC 3.1.4.17
Related Numbers: EC 3.1.4.17
Public MeSH Note: 2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1995-2007
History Note: 2008(1995)
Entry Combination: antagonists & inhibitors:Phosphodiesterase 3 Inhibitors
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Entry Combination: antagonists & inhibitors:Phosphodiesterase 3 Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0240466
Registry Number: EC 3.1.4.17
Related Numbers: EC 3.1.4.17
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
Terms: Cyclic Nucleotide Phosphodiesterases, Type 3 Preferred Term
Term UI T691986
Date02/21/2007
LexicalTag NON
ThesaurusID NLM (2008); Phosphodiesterase III
Term UI T270471
LexicalTag NON
ThesaurusID NLM (2008); Cyclic Nucleotide Phosphodiesterase PDE3 Family
Term UI T691987
Date02/21/2007
LexicalTag ABX
ThesaurusID NLM (2008); cGMP-Inhibited Phosphodiesterase
Term UI T421778
Date08/15/2000
LexicalTag ABX
ThesaurusID NLM (2008); cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
Term UI T421776
Date08/15/2000
LexicalTag ABX
ThesaurusID NLM (2008)

Cyclic Nucleotide Phosphodiesterases, Type 3 MeSH Descriptor Data 2023