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Cyclic Nucleotide Phosphodiesterases, Type 2 MeSH Descriptor Data 2023


MeSH Heading
Cyclic Nucleotide Phosphodiesterases, Type 2
Tree Number(s)
D08.811.277.352.640.150.200
D08.811.277.352.640.155.200
D12.776.476.008.200
D12.776.476.009.200
Unique ID
D054678
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054678
Scope Note
A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.
Entry Term(s)
Cyclic GMP-Stimulated Phosphodiesterase
Cyclic Nucleotide Phosphodiesterase PDE2 Family
Cyclic Nucleotide Phosphodiesterases, Type 2A
PDE2 Phosphodiesterase
PDE2 Phosphodiesterases
Phosphodiesterase 2A
cGMP-Dependent 3',5'-Cyclic Phosphodiesterase
Registry Number
EC 3.1.4.17
Related Numbers
EC 3.1.4.17
Public MeSH Note
2008; PDE2 PHOSPHODIESTERASE now CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2 was indexed under PHOSPHORIC DIESTER HYDROLASES 2000-2007
History Note
2008(2000)
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Cyclic Nucleotide Phosphodiesterases, Type 2 Preferred
Cyclic Nucleotide Phosphodiesterases, Type 2A Narrower
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