MeSH Browser

MeSH Heading: Cyclic Nucleotide Phosphodiesterases, Type 2
Tree Number(s): D08.811.277.352.640.150.200; D08.811.277.352.640.155.200; D12.776.476.008.200; D12.776.476.009.200
Unique ID: D054678
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054678
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.
Entry Term(s): Cyclic GMP-Stimulated Phosphodiesterase; Cyclic Nucleotide Phosphodiesterase PDE2 Family; Cyclic Nucleotide Phosphodiesterases, Type 2A; PDE2 Phosphodiesterase; PDE2 Phosphodiesterases; Phosphodiesterase 2A; cGMP-Dependent 3',5'-Cyclic Phosphodiesterase
Registry Number: EC 3.1.4.17
Related Numbers: EC 3.1.4.17
Public MeSH Note: 2008; PDE2 PHOSPHODIESTERASE now CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2 was indexed under PHOSPHORIC DIESTER HYDROLASES 2000-2007
History Note: 2008(2000)
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0368692
Registry Number: EC 3.1.4.17
Related Numbers: EC 3.1.4.17
Scope Note: A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.
Terms: Cyclic Nucleotide Phosphodiesterases, Type 2 Preferred Term
Term UI T691909
Date02/21/2007
LexicalTag NON
ThesaurusID NLM (2008); Cyclic GMP-Stimulated Phosphodiesterase
Term UI T691913
Date02/21/2007
LexicalTag ABX
ThesaurusID NLM (2008); Cyclic Nucleotide Phosphodiesterase PDE2 Family
Term UI T691911
Date02/21/2007
LexicalTag ABX
ThesaurusID NLM (2008); PDE2 Phosphodiesterase
Term UI T422789
Date08/29/2000
LexicalTag ABX
ThesaurusID NLM (2008); PDE2 Phosphodiesterases
Term UI T691910
Date02/21/2007
LexicalTag ABX
ThesaurusID NLM (2008)

Cyclic Nucleotide Phosphodiesterases, Type 2 MeSH Descriptor Data 2023