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Cyclic Nucleotide Phosphodiesterases, Type 5 MeSH Descriptor Data 2023


MeSH Heading
Cyclic Nucleotide Phosphodiesterases, Type 5
Tree Number(s)
D08.811.277.352.640.150.500
D08.811.277.352.640.155.500
D12.776.476.008.500
D12.776.476.009.500
Unique ID
D054706
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054706
Scope Note
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
Entry Term(s)
PDE5 Phosphodiesterases
Phosphodiesterase 5
Phosphodiesterase 5A
Phosphodiesterase 5A, cGMP-Specific
Phosphodiesterase Type 5
Phosphodiesterase Type V
Phosphodiesterase V
Phosphodiesterase-5
cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase
Registry Number
EC 3.1.4.35
Related Numbers
EC 3.1.4.17
Public MeSH Note
2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5 was indexed under 3',5'-CYCLIC-GMP PHOSPHODIESTERASE 1998-2007
History Note
2008(1998)
Entry Combination
antagonists & inhibitors:Phosphodiesterase 5 Inhibitors
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
Cyclic Nucleotide Phosphodiesterases, Type 5 Preferred
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