MeSH Browser

MeSH Heading: mu-Crystallins
Tree Number(s): D08.811.682.662.436; D12.776.306.366.888
Unique ID: D000090803
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000090803
Scope Note: A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.
Entry Term(s): CRYM Protein; Crystallin mu; Ketimine Reductase mu-Crystallin; NADP-Regulated Thyroid Hormone Binding Protein; THBP Protein
Registry Number: EC 1.5.1.25
Related Numbers: 147681-64-9
Public MeSH Note: 2022; for CRYSTALLIN MU see under CRYSTALLINS (1992-2021)
History Note: 2022(1992)
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000747331
Registry Number: EC 1.5.1.25
Related Numbers: 147681-64-9
Scope Note: A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.
Terms: mu-Crystallins Preferred Term
Term UI T001105132
Date04/23/2021
LexicalTag NON
ThesaurusID NLM (2022); NADP-Regulated Thyroid Hormone Binding Protein
Term UI T001107405
Date06/02/2021
LexicalTag NON
ThesaurusID NLM (2022); CRYM Protein
Term UI T001107387
Date06/02/2021
LexicalTag ABX
ThesaurusID NLM (2022); THBP Protein
Term UI T001107406
Date06/02/2021
LexicalTag ABX
ThesaurusID NLM (2022); Crystallin mu
Term UI T001107385
Date06/02/2021
LexicalTag NON
ThesaurusID NLM (2022); Ketimine Reductase mu-Crystallin
Term UI T001107386
Date06/02/2021
LexicalTag NON
ThesaurusID NLM (2022)

mu-Crystallins MeSH Descriptor Data 2023