- Concept UI
- M0013632
- Registry Numbers
- EC 1.5.1.5
- Scope Note
- An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
- Terms
-
Methylenetetrahydrofolate Dehydrogenase (NADP)
Preferred Term
Term UI
T535626
Date03/14/2003
LexicalTag
ABX
ThesaurusID
NLM (2004)
-
Methylenetetrahydrofolate Dehydrogenase
Term UI
T026094
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1975)
-
Methylenetetrahydrofolate Dehydrogenase (NADP+)
Term UI
T026096
Date04/21/1989
LexicalTag
ABX
ThesaurusID
NLM (1990)