MeSH Browser

MeSH Heading: Avapritinib
Tree Number(s): D03.383.129.539.140; D03.383.129.578.113; D03.383.931.284
Unique ID: D000099289
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099289
Scope Note: A tyrosine kinase receptor inhibitor that targets mutants of PROTO-ONCOGENE PROTEIN KIT and PLATELET-DERIVED GROWTH FACTOR ALPHA RECEPTOR.
Entry Term(s): (1S)-1-(4-Fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-yl)-1-piperazinyl)-5-pyrimidinyl)ethanamine; 5-Pyrimidinemethanamine, alpha-(4-fluorophenyl)-alpha-methyl-2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo(2,1-f)(1,2,4)triazin-4-yl)-1-piperazinyl)-, (alphaS)-; Ayvakit; BLU-285
Pharm Action: Antineoplastic Agents
Registry Numbers: 0
Public MeSH Note: 2026; AVAPRITINIB was indexed under PYRAZOLES; PYRROLES; TRIAZINES 2020-2025
History Note: 2026 (2020)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Avapritinib MeSH Descriptor Data 2026