MeSH Browser

MeSH Heading: Ryanodine
Tree Number(s): D02.455.849.291.686; D03.132.740; D03.383.129.578.805
Unique ID: D012433
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012433
Scope Note: A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
CAS Type 1 Name: Ryanodol, 3-(1H-pyrrole-2-carboxylate)
Previous Indexing: Alkaloids (1970-1974)
Public MeSH Note: 91; was see under ALKALOIDS 1975-90
History Note: 91(75); was see under ALKALOIDS 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Ryanodine MeSH Descriptor Data 2025