MeSH Browser

MeSH Heading: Matrix Metalloproteinase 2
Tree Number(s): D08.811.277.656.300.480.205.352; D08.811.277.656.300.480.252.420; D08.811.277.656.300.480.525.700.150; D08.811.277.656.675.374.205.352; D08.811.277.656.675.374.252.420; D08.811.277.656.675.374.525.700.150; D12.776.467.836.150
Unique ID: D020778
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020778
Scope Note: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
Entry Term(s): 72-kDa Gelatinase; 72-kDa Type IV Collagenase; Gelatinase A; MMP-2 Metalloproteinase; MMP2 Metalloproteinase; Matrix Metalloproteinase-2
Previous Indexing: Gelatinases (1992-1999); Metalloendopeptidases (1992-1999)
Public MeSH Note: 2000; see GELATINASE A 2000-2006; MATRIX METALLOPROTEINASE 2 was indexed under GELATINASES & METALLOPROTEINASES 1992-1999
History Note: 2007(2000)
Entry Combination: antagonists & inhibitors:Matrix Metalloproteinase Inhibitors
Date Established: 2000/01/01
Date of Entry: 1999/11/04
Revision Date: 2021/05/21

Entry Combination: antagonists & inhibitors:Matrix Metalloproteinase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Metalloendopeptidases [D08.811.277.656.300.480]
        
        Collagenases [D08.811.277.656.300.480.205]
        
        Matrix Metalloproteinase 1 [D08.811.277.656.300.480.205.351]
        
        Matrix Metalloproteinase 2 [D08.811.277.656.300.480.205.352]
        
        Matrix Metalloproteinase 8 [D08.811.277.656.300.480.205.358]
        
        Matrix Metalloproteinase 9 [D08.811.277.656.300.480.205.360]
        
        Matrix Metalloproteinase 13 [D08.811.277.656.300.480.205.363]
        
        Microbial Collagenase [D08.811.277.656.300.480.205.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Metalloendopeptidases [D08.811.277.656.300.480]
        
        Gelatinases [D08.811.277.656.300.480.252]
        
        Matrix Metalloproteinase 2 [D08.811.277.656.300.480.252.420]
        
        Matrix Metalloproteinase 9 [D08.811.277.656.300.480.252.445]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Metalloendopeptidases [D08.811.277.656.300.480]
        
        Matrix Metalloproteinases [D08.811.277.656.300.480.525]
        
        Matrix Metalloproteinases, Secreted [D08.811.277.656.300.480.525.700]
        
        Bone Morphogenetic Protein 1 [D08.811.277.656.300.480.525.700.049]
        
        Matrix Metalloproteinase 1 [D08.811.277.656.300.480.525.700.100]
        
        Matrix Metalloproteinase 2 [D08.811.277.656.300.480.525.700.150]
        
        Matrix Metalloproteinase 3 [D08.811.277.656.300.480.525.700.200]
        
        Matrix Metalloproteinase 7 [D08.811.277.656.300.480.525.700.250]
        
        Matrix Metalloproteinase 8 [D08.811.277.656.300.480.525.700.300]
        
        Matrix Metalloproteinase 9 [D08.811.277.656.300.480.525.700.350]
        
        Matrix Metalloproteinase 10 [D08.811.277.656.300.480.525.700.400]
        
        Matrix Metalloproteinase 11 [D08.811.277.656.300.480.525.700.450]
        
        Matrix Metalloproteinase 12 [D08.811.277.656.300.480.525.700.500]
        
        Matrix Metalloproteinase 13 [D08.811.277.656.300.480.525.700.550]
        
        Matrix Metalloproteinase 20 [D08.811.277.656.300.480.525.700.800]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloendopeptidases [D08.811.277.656.675.374]
        
        Collagenases [D08.811.277.656.675.374.205]
        
        Matrix Metalloproteinase 1 [D08.811.277.656.675.374.205.351]
        
        Matrix Metalloproteinase 2 [D08.811.277.656.675.374.205.352]
        
        Matrix Metalloproteinase 8 [D08.811.277.656.675.374.205.358]
        
        Matrix Metalloproteinase 9 [D08.811.277.656.675.374.205.360]
        
        Matrix Metalloproteinase 13 [D08.811.277.656.675.374.205.363]
        
        Microbial Collagenase [D08.811.277.656.675.374.205.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloendopeptidases [D08.811.277.656.675.374]
        
        Gelatinases [D08.811.277.656.675.374.252]
        
        Matrix Metalloproteinase 2 [D08.811.277.656.675.374.252.420]
        
        Matrix Metalloproteinase 9 [D08.811.277.656.675.374.252.445]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloendopeptidases [D08.811.277.656.675.374]
        
        Matrix Metalloproteinases [D08.811.277.656.675.374.525]
        
        Matrix Metalloproteinases, Secreted [D08.811.277.656.675.374.525.700]
        
        Matrix Metalloproteinase 1 [D08.811.277.656.675.374.525.700.100]
        
        Matrix Metalloproteinase 2 [D08.811.277.656.675.374.525.700.150]
        
        Matrix Metalloproteinase 3 [D08.811.277.656.675.374.525.700.200]
        
        Matrix Metalloproteinase 7 [D08.811.277.656.675.374.525.700.250]
        
        Matrix Metalloproteinase 8 [D08.811.277.656.675.374.525.700.300]
        
        Matrix Metalloproteinase 9 [D08.811.277.656.675.374.525.700.350]
        
        Matrix Metalloproteinase 10 [D08.811.277.656.675.374.525.700.400]
        
        Matrix Metalloproteinase 11 [D08.811.277.656.675.374.525.700.450]
        
        Matrix Metalloproteinase 12 [D08.811.277.656.675.374.525.700.500]
        
        Matrix Metalloproteinase 13 [D08.811.277.656.675.374.525.700.550]
        
        Matrix Metalloproteinase 20 [D08.811.277.656.675.374.525.700.800]
        
        Tolloid-Like Metalloproteinases [D08.811.277.656.675.374.525.700.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Matrix Metalloproteinases, Secreted [D12.776.467.836]

Matrix Metalloproteinase 2 Preferred

Concept UI: M0328128
Scope Note: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
Terms: Matrix Metalloproteinase 2 Preferred Term
Term UI T664555
Date01/18/2006
LexicalTag NON
ThesaurusID NLM (2007); 72-kDa Type IV Collagenase
Term UI T236446
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Matrix Metalloproteinase-2
Term UI T236450
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); 72-kDa Gelatinase
Term UI T236445
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MMP-2 Metalloproteinase
Term UI T664567
Date01/18/2006
LexicalTag ABX
ThesaurusID NLM (2007); MMP2 Metalloproteinase
Term UI T664581
Date01/18/2006
LexicalTag ABX
ThesaurusID NLM (2007); Gelatinase A
Term UI T236451
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

Matrix Metalloproteinase 2 MeSH Descriptor Data 2025