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Complement C3 Nephritic Factor MeSH Descriptor Data 2023


MeSH Heading
Complement C3 Nephritic Factor
Tree Number(s)
D12.776.124.486.274.920.287
D12.776.124.486.485.114.323.300
D12.776.124.790.651.114.323.300
D12.776.377.715.548.114.323.300
Unique ID
D003178
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003178
Scope Note
An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
Entry Term(s)
C 3 Nephritic Factor
C3 NeF
C3 NeF IgG Autoantibodies
C3 NeF IgG Autoantibody
C3 Nephritic Factor
C3NeF IgG Autoantibodies
C3NeF IgG Autoantibody
Complement 3 Nephritic Factor
Pharm Action
Immunologic Factors
Complement Inactivating Agents
Registry Number
0
Previous Indexing
Blood Proteins (1966-1977)
Complement 3 (1975-1977)
Public MeSH Note
2006; see COMPLEMENT 3 NEPHRITIC FACTOR 1991-2005, see COMPLEMENT INACTIVATORS 1978-1990
History Note
2006 (1978)
Date Established
1991/01/01
Date of Entry
1977/05/20
Revision Date
2022/04/13
Complement C3 Nephritic Factor Preferred
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