- Concept UI
- M0004930
- Registry Number
- 0
- Scope Note
- An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
- Terms
-
Complement C3 Nephritic Factor
Preferred Term
Term UI
T631343
Date02/23/2005
LexicalTag
NON
ThesaurusID
NLM (2006)
-
Complement 3 Nephritic Factor
Term UI
T009280
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1978)
-
C 3 Nephritic Factor
Term UI
T009281
Date04/15/1981
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
C3 Nephritic Factor
Term UI
T009282
Date05/20/1977
LexicalTag
NON
ThesaurusID
UNK (19XX)