MeSH Browser

MeSH Heading: Complement C3 Nephritic Factor
Tree Number(s): D12.776.124.486.274.920.287; D12.776.124.486.485.114.323.300; D12.776.124.790.651.114.323.300; D12.776.377.715.548.114.323.300
Unique ID: D003178
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003178
Scope Note: An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
Entry Term(s): C 3 Nephritic Factor; C3 NeF; C3 NeF IgG Autoantibodies; C3 NeF IgG Autoantibody; C3 Nephritic Factor; C3NeF IgG Autoantibodies; C3NeF IgG Autoantibody; Complement 3 Nephritic Factor
Pharm Action: Immunologic Factors
Complement Inactivating Agents
Registry Numbers: 0
Previous Indexing: Blood Proteins (1966-1977); Complement 3 (1975-1977)
Public MeSH Note: 2006; see COMPLEMENT 3 NEPHRITIC FACTOR 1991-2005, see COMPLEMENT INACTIVATORS 1978-1990
History Note: 2006 (1978)
Date Established: 1991/01/01
Date of Entry: 1977/05/20
Revision Date: 2022/04/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Complement System Proteins [D12.776.124.486.274]
        
        Complement Inactivator Proteins [D12.776.124.486.274.920]
        
        Membrane Cofactor Protein [D12.776.124.486.274.920.124]
        
        Complement C1 Inactivator Proteins [D12.776.124.486.274.920.250]
        
        Complement C3 Nephritic Factor [D12.776.124.486.274.920.287]
        
        Complement C3b Inactivator Proteins [D12.776.124.486.274.920.325]
        
        Complement C4b-Binding Protein [D12.776.124.486.274.920.662]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Antibodies [D12.776.124.486.485.114]
        
        Autoantibodies [D12.776.124.486.485.114.323]
        
        Anti-Citrullinated Protein Antibodies [D12.776.124.486.485.114.323.095]
        
        Antibodies, Antineutrophil Cytoplasmic [D12.776.124.486.485.114.323.190]
        
        Antibodies, Antinuclear [D12.776.124.486.485.114.323.204]
        
        Antibodies, Antiphospholipid [D12.776.124.486.485.114.323.210]
        
        Complement C3 Nephritic Factor [D12.776.124.486.485.114.323.300]
        
        Immunoconglutinins [D12.776.124.486.485.114.323.390]
        
        Immunoglobulins, Thyroid-Stimulating [D12.776.124.486.485.114.323.480]
        
        Rheumatoid Factor [D12.776.124.486.485.114.323.732]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Antibodies [D12.776.124.790.651.114]
        
        Autoantibodies [D12.776.124.790.651.114.323]
        
        Anti-Citrullinated Protein Antibodies [D12.776.124.790.651.114.323.095]
        
        Antibodies, Antineutrophil Cytoplasmic [D12.776.124.790.651.114.323.190]
        
        Antibodies, Antinuclear [D12.776.124.790.651.114.323.204]
        
        Antibodies, Antiphospholipid [D12.776.124.790.651.114.323.210]
        
        Complement C3 Nephritic Factor [D12.776.124.790.651.114.323.300]
        
        Immunoconglutinins [D12.776.124.790.651.114.323.390]
        
        Immunoglobulins, Thyroid-Stimulating [D12.776.124.790.651.114.323.480]
        
        Rheumatoid Factor [D12.776.124.790.651.114.323.732]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Antibodies [D12.776.377.715.548.114]
        
        Autoantibodies [D12.776.377.715.548.114.323]
        
        Anti-Citrullinated Protein Antibodies [D12.776.377.715.548.114.323.095]
        
        Antibodies, Antineutrophil Cytoplasmic [D12.776.377.715.548.114.323.190]
        
        Antibodies, Antinuclear [D12.776.377.715.548.114.323.204]
        
        Antibodies, Antiphospholipid [D12.776.377.715.548.114.323.210]
        
        Complement C3 Nephritic Factor [D12.776.377.715.548.114.323.300]
        
        Immunoconglutinins [D12.776.377.715.548.114.323.390]
        
        Immunoglobulins, Thyroid-Stimulating [D12.776.377.715.548.114.323.480]
        
        Rheumatoid Factor [D12.776.377.715.548.114.323.732]

Complement C3 Nephritic Factor Preferred

Concept UI: M0004930
Registry Numbers: 0
Scope Note: An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
Terms: Complement C3 Nephritic Factor Preferred Term
Term UI T631343
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); C3 NeF IgG Autoantibody
Term UI T001112277
Date09/24/2021
LexicalTag ABX
ThesaurusID NLM (2023); C3NeF IgG Autoantibodies
Term UI T001112278
Date09/24/2021
LexicalTag ABX
ThesaurusID NLM (2023); C3NeF IgG Autoantibody
Term UI T001112279
Date09/24/2021
LexicalTag ABX
ThesaurusID NLM (2023); C3 Nephritic Factor
Term UI T009282
Date05/20/1977
LexicalTag ABX
ThesaurusID UNK (19XX); Complement 3 Nephritic Factor
Term UI T009280
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); C3 NeF IgG Autoantibodies
Term UI T001112276
Date09/24/2021
LexicalTag ABX
ThesaurusID NLM (2023); C 3 Nephritic Factor
Term UI T009281
Date04/15/1981
LexicalTag NON
ThesaurusID UNK (19XX); C3 NeF
Term UI T001112275
Date09/24/2021
LexicalTag ABB
ThesaurusID NLM (2023)

Complement C3 Nephritic Factor MeSH Descriptor Data 2024