MeSH Browser

MeSH Heading: ADAM10 Protein
Tree Number(s): D08.811.277.656.675.374.102.250; D09.400.430.500.250; D12.776.395.033.250
Unique ID: D000072197
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072197
Scope Note: A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.
Entry Term(s): ADAM-10 Protein; CD156c Antigen; CD156w Antigen; Disintegrin and Metalloproteinase Domain-Containing Protein 10
Previous Indexing: ADAM Proteins (2004-2016); Amyloid Precursor Protein Secretases (2007-2016); Membrane Proteins (2004-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000616517
Scope Note: A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.
Terms: ADAM10 Protein Preferred Term
Term UI T000898456
Date04/07/2016
LexicalTag ACX
ThesaurusID NLM (2017); Disintegrin and Metalloproteinase Domain-Containing Protein 10
Term UI T000900379
Date05/04/2016
LexicalTag NON
ThesaurusID NLM (2017); ADAM-10 Protein
Term UI T000898457
Date04/07/2016
LexicalTag ACX
ThesaurusID NLM (2017); CD156c Antigen
Term UI T000898459
Date04/07/2016
LexicalTag ABX
ThesaurusID NLM (2017); CD156w Antigen
Term UI T000898460
Date04/07/2016
LexicalTag ABX
ThesaurusID NLM (2017)

ADAM10 Protein MeSH Descriptor Data 2025