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Trisomy 18 Syndrome
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Trisomy 18 Syndrome
Tree Number(s)
C14.240.400.975
C14.280.400.975
C16.131.077.929
C16.131.240.400.968
C16.131.260.932
C16.320.180.932
Unique ID
D000073842
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000073842
Scope Note
A chromosome disorder associated with
TRISOMY
of all or part of
CHROMOSOME 18
. Clinical manifestations include
INTRAUTERINE GROWTH RETARDATION
;
CLEFT PALATE
;
CONGENITAL HEART DEFECTS
;
MICROCEPHALY
;
MICROGNATHIA
and clenched fists with overlapping fingers. Most affected fetuses do not survive to birth. Those who survive through their first year often have severe
INTELLECTUAL DISABILITY
.
Entry Term(s)
Complete Trisomy 18 Syndrome
Edwards Syndrome
Mosaic Trisomy 18 Syndrome
Trisomy 18
Trisomy E Syndrome
Public MeSH Note
2018; TRISOMY 18 was indexed under CHROMOSOMES, HUMAN, PAIR 18; and TRISOMY 2014-2017
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2018/05/23
Allowable Qualifiers
blood (BL)
cerebrospinal fluid (CF)
chemically induced (CI)
classification (CL)
complications (CO)
diagnosis (DI)
diagnostic imaging (DG)
diet therapy (DH)
drug therapy (DT)
economics (EC)
embryology (EM)
enzymology (EN)
epidemiology (EP)
ethnology (EH)
etiology (ET)
genetics (GE)
history (HI)
immunology (IM)
metabolism (ME)
microbiology (MI)
mortality (MO)
nursing (NU)
parasitology (PS)
pathology (PA)
physiopathology (PP)
prevention & control (PC)
psychology (PX)
radiotherapy (RT)
rehabilitation (RH)
surgery (SU)
therapy (TH)
urine (UR)
veterinary (VE)
virology (VI)
Cardiovascular Diseases [C14]
Cardiovascular Abnormalities [C14.240]
Heart Defects, Congenital [C14.240.400]
22q11 Deletion Syndrome [C14.240.400.021]
Alagille Syndrome [C14.240.400.044]
Aortic Coarctation [C14.240.400.090]
Aortico-Ventricular Tunnel [C14.240.400.118]
Arrhythmogenic Right Ventricular Dysplasia [C14.240.400.145]
Barth Syndrome [C14.240.400.172]
Bicuspid Aortic Valve Disease [C14.240.400.186]
Cor Triatriatum [C14.240.400.200]
Coronary Vessel Anomalies [C14.240.400.210]
Crisscross Heart [C14.240.400.220]
Dextrocardia [C14.240.400.280]
Ductus Arteriosus, Patent [C14.240.400.340]
Ebstein Anomaly [C14.240.400.395]
Ectopia Cordis [C14.240.400.422]
Eisenmenger Complex [C14.240.400.450]
Heart Septal Defects [C14.240.400.560]
Heterotaxy Syndrome [C14.240.400.592]
Hypoplastic Left Heart Syndrome [C14.240.400.625]
Isolated Noncompaction of the Ventricular Myocardium [C14.240.400.660]
LEOPARD Syndrome [C14.240.400.695]
Levocardia [C14.240.400.701]
Marfan Syndrome [C14.240.400.725]
Noonan Syndrome [C14.240.400.787]
Quadricuspid Aortic Valve [C14.240.400.818]
Tetralogy of Fallot [C14.240.400.849]
Transposition of Great Vessels [C14.240.400.915]
Tricuspid Atresia [C14.240.400.920]
Trilogy of Fallot [C14.240.400.960]
Trisomy 13 Syndrome [C14.240.400.970]
Trisomy 18 Syndrome [C14.240.400.975]
Turner Syndrome [C14.240.400.980]
Univentricular Heart [C14.240.400.990]
Cardiovascular Diseases [C14]
Heart Diseases [C14.280]
Heart Defects, Congenital [C14.280.400]
22q11 Deletion Syndrome [C14.280.400.044]
Aortic Coarctation [C14.280.400.090]
Aortico-Ventricular Tunnel [C14.280.400.118]
Arrhythmogenic Right Ventricular Dysplasia [C14.280.400.145]
Barth Syndrome [C14.280.400.172]
Bicuspid Aortic Valve Disease [C14.280.400.186]
Cor Triatriatum [C14.280.400.200]
Coronary Vessel Anomalies [C14.280.400.210]
Crisscross Heart [C14.280.400.220]
Dextrocardia [C14.280.400.280]
Ductus Arteriosus, Patent [C14.280.400.340]
Ebstein Anomaly [C14.280.400.395]
Eisenmenger Complex [C14.280.400.450]
Heart Septal Defects [C14.280.400.560]
Heterotaxy Syndrome [C14.280.400.592]
Hypoplastic Left Heart Syndrome [C14.280.400.625]
Isolated Noncompaction of the Ventricular Myocardium [C14.280.400.660]
LEOPARD Syndrome [C14.280.400.695]
Levocardia [C14.280.400.701]
Marfan Syndrome [C14.280.400.725]
Noonan Syndrome [C14.280.400.787]
Quadricuspid Aortic Valve [C14.280.400.818]
Tetralogy of Fallot [C14.280.400.849]
Transposition of Great Vessels [C14.280.400.915]
Tricuspid Atresia [C14.280.400.920]
Trilogy of Fallot [C14.280.400.960]
Trisomy 13 Syndrome [C14.280.400.970]
Trisomy 18 Syndrome [C14.280.400.975]
Turner Syndrome [C14.280.400.980]
Univentricular Heart [C14.280.400.990]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Abnormalities, Multiple [C16.131.077]
22q11 Deletion Syndrome [C16.131.077.019]
Alagille Syndrome [C16.131.077.065]
Angelman Syndrome [C16.131.077.095]
Barth Syndrome [C16.131.077.121]
Basal Cell Nevus Syndrome [C16.131.077.130]
Beckwith-Wiedemann Syndrome [C16.131.077.133]
Bloom Syndrome [C16.131.077.137]
Branchio-Oto-Renal Syndrome [C16.131.077.208]
Carney Complex [C16.131.077.229]
Ciliopathies [C16.131.077.245]
Cockayne Syndrome [C16.131.077.250]
Costello Syndrome [C16.131.077.256]
Cri-du-Chat Syndrome [C16.131.077.262]
De Lange Syndrome [C16.131.077.272]
Deaf-Blind Disorders [C16.131.077.299]
Donohue Syndrome [C16.131.077.313]
Down Syndrome [C16.131.077.327]
Ectodermal Dysplasia [C16.131.077.350]
Fraser Syndrome [C16.131.077.371]
Gardner Syndrome [C16.131.077.393]
Heterotaxy Syndrome [C16.131.077.401]
Holoprosencephaly [C16.131.077.410]
Incontinentia Pigmenti [C16.131.077.445]
Isolated Noncompaction of the Ventricular Myocardium [C16.131.077.477]
Laurence-Moon Syndrome [C16.131.077.509]
LEOPARD Syndrome [C16.131.077.525]
Loeys-Dietz Syndrome [C16.131.077.537]
Marfan Syndrome [C16.131.077.550]
Mobius Syndrome [C16.131.077.578]
Monilethrix [C16.131.077.592]
Nail-Patella Syndrome [C16.131.077.606]
Netherton Syndrome [C16.131.077.619]
Nevus, Sebaceous of Jadassohn [C16.131.077.633]
Oculocerebrorenal Syndrome [C16.131.077.662]
Orofaciodigital Syndromes [C16.131.077.676]
Pallister-Hall Syndrome [C16.131.077.690]
Pentalogy of Cantrell [C16.131.077.696]
POEMS Syndrome [C16.131.077.703]
Polycystic Kidney Diseases [C16.131.077.717]
Prader-Willi Syndrome [C16.131.077.730]
Prolidase Deficiency [C16.131.077.735]
Proteus Syndrome [C16.131.077.740]
Prune Belly Syndrome [C16.131.077.745]
Rubella Syndrome, Congenital [C16.131.077.790]
Rubinstein-Taybi Syndrome [C16.131.077.804]
Short Rib-Polydactyly Syndrome [C16.131.077.850]
Silver-Russell Syndrome [C16.131.077.855]
Smith-Lemli-Opitz Syndrome [C16.131.077.860]
Smith-Magenis Syndrome [C16.131.077.879]
Sotos Syndrome [C16.131.077.889]
Trichothiodystrophy Syndromes [C16.131.077.899]
Trisomy 13 Syndrome [C16.131.077.919]
Trisomy 18 Syndrome [C16.131.077.929]
Waardenburg Syndrome [C16.131.077.938]
Weill-Marchesani Syndrome [C16.131.077.941]
Wolf-Hirschhorn Syndrome [C16.131.077.944]
Zellweger Syndrome [C16.131.077.970]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Cardiovascular Abnormalities [C16.131.240]
Heart Defects, Congenital [C16.131.240.400]
22q11 Deletion Syndrome [C16.131.240.400.021]
Alagille Syndrome [C16.131.240.400.044]
Aortic Coarctation [C16.131.240.400.090]
Aortico-Ventricular Tunnel [C16.131.240.400.118]
Arrhythmogenic Right Ventricular Dysplasia [C16.131.240.400.145]
Barth Syndrome [C16.131.240.400.172]
Bicuspid Aortic Valve Disease [C16.131.240.400.186]
Cor Triatriatum [C16.131.240.400.200]
Coronary Vessel Anomalies [C16.131.240.400.210]
Crisscross Heart [C16.131.240.400.220]
Dextrocardia [C16.131.240.400.280]
Ductus Arteriosus, Patent [C16.131.240.400.340]
Ebstein Anomaly [C16.131.240.400.395]
Ectopia Cordis [C16.131.240.400.422]
Eisenmenger Complex [C16.131.240.400.450]
Heart Septal Defects [C16.131.240.400.560]
Heterotaxy Syndrome [C16.131.240.400.592]
Hypoplastic Left Heart Syndrome [C16.131.240.400.625]
Isolated Noncompaction of the Ventricular Myocardium [C16.131.240.400.655]
LEOPARD Syndrome [C16.131.240.400.685]
Levocardia [C16.131.240.400.701]
Long QT Syndrome [C16.131.240.400.715]
Marfan Syndrome [C16.131.240.400.720]
Noonan Syndrome [C16.131.240.400.784]
Quadricuspid Aortic Valve [C16.131.240.400.817]
Tetralogy of Fallot [C16.131.240.400.849]
Transposition of Great Vessels [C16.131.240.400.915]
Tricuspid Atresia [C16.131.240.400.920]
Trilogy of Fallot [C16.131.240.400.960]
Trisomy 13 Syndrome [C16.131.240.400.965]
Trisomy 18 Syndrome [C16.131.240.400.968]
Turner Syndrome [C16.131.240.400.970]
Univentricular Heart [C16.131.240.400.975]
Wolff-Parkinson-White Syndrome [C16.131.240.400.980]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Chromosome Disorders [C16.131.260]
22q11 Deletion Syndrome [C16.131.260.019]
Angelman Syndrome [C16.131.260.040]
Beckwith-Wiedemann Syndrome [C16.131.260.080]
Branchio-Oto-Renal Syndrome [C16.131.260.090]
Cri-du-Chat Syndrome [C16.131.260.190]
De Lange Syndrome [C16.131.260.210]
Down Syndrome [C16.131.260.260]
Holoprosencephaly [C16.131.260.380]
Jacobsen Distal 11q Deletion Syndrome [C16.131.260.440]
Prader-Willi Syndrome [C16.131.260.700]
Rubinstein-Taybi Syndrome [C16.131.260.790]
Sex Chromosome Disorders [C16.131.260.830]
Silver-Russell Syndrome [C16.131.260.870]
Smith-Magenis Syndrome [C16.131.260.887]
Sotos Syndrome [C16.131.260.905]
Trisomy 13 Syndrome [C16.131.260.923]
Trisomy 18 Syndrome [C16.131.260.932]
WAGR Syndrome [C16.131.260.940]
Williams Syndrome [C16.131.260.970]
Wolf-Hirschhorn Syndrome [C16.131.260.985]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Chromosome Disorders [C16.320.180]
22q11 Deletion Syndrome [C16.320.180.019]
Angelman Syndrome [C16.320.180.040]
Beckwith-Wiedemann Syndrome [C16.320.180.080]
Branchio-Oto-Renal Syndrome [C16.320.180.090]
Cri-du-Chat Syndrome [C16.320.180.190]
De Lange Syndrome [C16.320.180.210]
Down Syndrome [C16.320.180.260]
Holoprosencephaly [C16.320.180.380]
Jacobsen Distal 11q Deletion Syndrome [C16.320.180.440]
Prader-Willi Syndrome [C16.320.180.700]
Rubinstein-Taybi Syndrome [C16.320.180.790]
Sex Chromosome Disorders [C16.320.180.830]
Silver-Russell Syndrome [C16.320.180.870]
Smith-Magenis Syndrome [C16.320.180.887]
Sotos Syndrome [C16.320.180.905]
Trisomy 13 Syndrome [C16.320.180.923]
Trisomy 18 Syndrome [C16.320.180.932]
WAGR Syndrome [C16.320.180.940]
Williams Syndrome [C16.320.180.970]
Wolf-Hirschhorn Syndrome [C16.320.180.985]
Expand All
Collapse All
Trisomy 18 Syndrome
Preferred
Concept UI
M000624074
Scope Note
A chromosome disorder associated with
TRISOMY
of all or part of
CHROMOSOME 18
. Clinical manifestations include
INTRAUTERINE GROWTH RETARDATION
;
CLEFT PALATE
;
CONGENITAL HEART DEFECTS
;
MICROCEPHALY
;
MICROGNATHIA
and clenched fists with overlapping fingers. Most affected fetuses do not survive to birth. Those who survive through their first year often have severe
INTELLECTUAL DISABILITY
.
Terms
Trisomy 18 Syndrome
Preferred Term
Term UI
T842616
Date
04/18/2013
LexicalTag
NON
ThesaurusID
GHR (2014)
Trisomy 18
Narrower
Concept UI
M0583946
Terms
Trisomy 18
Preferred Term
Term UI
T842613
Date
04/18/2013
LexicalTag
NON
ThesaurusID
GHR (2014)
Mosaic Trisomy 18 Syndrome
Narrower
Concept UI
M000624083
Terms
Mosaic Trisomy 18 Syndrome
Preferred Term
Term UI
T000912192
Date
11/28/2016
LexicalTag
NON
ThesaurusID
NLM (2018)
Complete Trisomy 18 Syndrome
Narrower
Concept UI
M000641927
Terms
Complete Trisomy 18 Syndrome
Preferred Term
Term UI
T842614
Date
04/18/2013
LexicalTag
NON
ThesaurusID
GHR (2014)
Edwards Syndrome
Term UI
T842615
Date
04/18/2013
LexicalTag
EPO
ThesaurusID
GHR (2014)
Trisomy E Syndrome
Narrower
Concept UI
M000642293
Terms
Trisomy E Syndrome
Preferred Term
Term UI
T842617
Date
04/18/2013
LexicalTag
NON
ThesaurusID
GHR (2014)
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