MeSH Browser

MeSH Heading: Sotos Syndrome
Tree Number(s): C16.131.077.889; C16.131.260.905; C16.320.180.905
Unique ID: D058495
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D058495
Scope Note: Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.
Entry Term(s): Cerebral Gigantism; Sotos Sequence; Sotos' Syndrome
Previous Indexing: Acromegaly (1977-2010); Gigantism (1977-2010)
See Also: Fetal Macrosomia; Gigantism
Public MeSH Note: 2011
History Note: 2011
Date Established: 2011/01/01
Date of Entry: 2010/06/25
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0542875
Scope Note: Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.
Terms: Sotos Syndrome Preferred Term
Term UI T764493
Date01/21/2010
LexicalTag EPO
ThesaurusID; Cerebral Gigantism
Term UI T764494
Date01/21/2010
LexicalTag NON
ThesaurusID; Sotos Sequence
Term UI T842476
Date04/18/2013
LexicalTag EPO
ThesaurusID GHR (2014); Sotos' Syndrome
Term UI T842477
Date04/18/2013
LexicalTag EPO
ThesaurusID GHR (2014)

Sotos Syndrome MeSH Descriptor Data 2025