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Disintegrins MeSH Descriptor Data 2021


MeSH Heading
Disintegrins
Tree Number(s)
D12.644.138
Unique ID
D019483
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019483
Annotation
polypeptides from snake venom; platelet aggregation inhib
Scope Note
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Entry Term(s)
Disintegrin
Pharm Action
Platelet Aggregation Inhibitors
Registry Number
0
Previous Indexing
Peptides (1992-1996)
Venoms (1992-1994)
Public MeSH Note
97; DISINTEGRINS was indexed under PEPTIDES 1992-96 & VENOMS 1992-94
Online Note
use DISINTEGRINS (NM) to search DISINTEGRINS 1992-96
History Note
97; was DISINTEGRINS (NM) 1992-96
Date Established
1997/01/01
Date of Entry
1996/06/10
Revision Date
2020/05/27
Disintegrins Preferred
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