MeSH Browser

MeSH Heading: Protein Sorting Signals
Tree Number(s): D12.644.770; G02.111.570.060.670
Unique ID: D021382
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D021382
Scope Note: Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
Entry Term(s): Leader Peptide; Leader Sequences, Peptide; Leader Signal Peptides; Peptide Leader Sequences; Peptide Signal Sequences; Signal Peptide; Signal Peptides; Signal Sequence, Peptide; Signal Sequences; Signal Sequences, Peptide
NLM Classification #: QU 68
See Also: Protein Transport; Signal Recognition Particle
Public MeSH Note: 2001; see Signal Peptides 1986-2000
History Note: 2001(1986)
Date Established: 2001/01/01
Date of Entry: 2000/07/06
Revision Date: 2008/07/08

Concept UI: M0019841
Scope Note: Highly hydrophobic amino acid sequences of proteins that must cross through membranes to arrive at their functioning cellular location (such as secreted and membrane proteins). They are 15 to 60 amino acids long and reside at the amino-terminus (leader signal peptides) or internally. By binding to signal recognition particles, these sequences direct nascent protein-ribosome complexes to a membrane where the protein is inserted during translation. Signal peptides direct translational uptake of the protein by various membranes -endoplamic reticulum, mitochondrial, chloroplast, peroxisomal, etc. Leader signal sequences on non-membrane proteins are ultimately removed by specific peptidases.
Terms: Signal Peptides Preferred Term
Term UI T037789
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1986); Peptide Signal Sequences
Term UI T037785
Date07/28/1988
LexicalTag NON
ThesaurusID UNK (19XX); Signal Sequence, Peptide
Term UI T037786
Date07/28/1988
LexicalTag NON
ThesaurusID UNK (19XX); Signal Sequences, Peptide
Term UI T037787
Date06/06/1985
LexicalTag NON
ThesaurusID UNK (19XX); Signal Peptide
Term UI T037788
Date07/28/1988
LexicalTag NON
ThesaurusID UNK (19XX); Signal Sequences
Term UI T037792
Date04/10/1996
LexicalTag NON
ThesaurusID NLM (1997)

Concept UI: M0358903
Terms: Leader Signal Peptides Preferred Term
Term UI T037784
Date06/06/1985
LexicalTag NON
ThesaurusID UNK (19XX); Leader Peptide
Term UI T037783
Date06/06/1985
LexicalTag NON
ThesaurusID UNK (19XX); Leader Sequences, Peptide
Term UI T037790
Date06/06/1985
LexicalTag NON
ThesaurusID UNK (19XX); Peptide Leader Sequences
Term UI T037791
Date06/06/1985
LexicalTag NON
ThesaurusID UNK (19XX)

Protein Sorting Signals MeSH Descriptor Data 2025