MeSH Browser

MeSH Heading: Trefoil Factors
Tree Number(s): D12.644.937
Unique ID: D000071162
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071162
Scope Note: A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. Their structure is highly conserved and is defined by a three-leaved (trefoil) domain of 42 or 43 amino acids; it includes six cysteines that create the trefoil structure through disulfide bridges. Trefoil peptides may form dimers with each other, or associate with MUCINS and other factors. They are important for maintaining epithelial integrity and for protection from noxious agents.
Entry Term(s): TFF Peptide; TFF Peptides; Trefoil Factor; Trefoil Factor Family Peptides; Trefoil Factor Family Proteins; Trefoil Peptide; Trefoil Peptides; Trefoil Protein; Trefoil Proteins
Registry Numbers: 0
Previous Indexing: Mucins (1992-2016); Peptides (1992-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]

Trefoil Factors Preferred

Concept UI: M000613336
Registry Numbers: 0
Scope Note: A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. Their structure is highly conserved and is defined by a three-leaved (trefoil) domain of 42 or 43 amino acids; it includes six cysteines that create the trefoil structure through disulfide bridges. Trefoil peptides may form dimers with each other, or associate with MUCINS and other factors. They are important for maintaining epithelial integrity and for protection from noxious agents.
Terms: Trefoil Factors Preferred Term
Term UI T000893174
Date01/05/2016
LexicalTag NON
ThesaurusID NLM (2017); Trefoil Peptides
Term UI T000893177
Date01/05/2016
LexicalTag NON
ThesaurusID NLM (2017); TFF Peptides
Term UI T000893178
Date01/05/2016
LexicalTag ABX
ThesaurusID NLM (2017); Trefoil Proteins
Term UI T000893179
Date01/05/2016
LexicalTag NON
ThesaurusID NLM (2017); Trefoil Factor Family Peptides
Term UI T000893180
Date01/05/2016
LexicalTag NON
ThesaurusID NLM (2017); Trefoil Factor Family Proteins
Term UI T000893181
Date01/05/2016
LexicalTag NON
ThesaurusID NLM (2017); TFF Peptide
Term UI T001010405
Date03/17/2020
LexicalTag NON
ThesaurusID NLM (2021); Trefoil Factor
Term UI T001010404
Date03/17/2020
LexicalTag NON
ThesaurusID NLM (2021); Trefoil Protein
Term UI T001010407
Date03/17/2020
LexicalTag NON
ThesaurusID NLM (2021); Trefoil Peptide
Term UI T001010406
Date03/17/2020
LexicalTag NON
ThesaurusID NLM (2021)

Trefoil Factors MeSH Descriptor Data 2024