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Aromatase MeSH Descriptor Data 2022


MeSH Heading
Aromatase
Tree Number(s)
D08.244.453.489.500
D08.244.453.915.099
D08.811.682.690.708.170.447.500
D08.811.682.690.708.170.915.099
D12.776.422.220.453.489.500
D12.776.422.220.453.915.099
Unique ID
D001141
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D001141
Scope Note
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Entry Term(s)
Androstenedione Aromatase
CYP 19
CYP19
CYP19 Protein
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
Registry Number
EC 1.14.14.1
Previous Indexing
Androstanes (1972-1974)
Estrogens (1972-1974)
Oxidoreductases (1972-1974)
Public MeSH Note
86; was see under OXIDOREDUCTASES 1975-85
History Note
86(75); was see under OXIDOREDUCTASES 1975-85
Entry Combination
antagonists & inhibitors:Aromatase Inhibitors
Date Established
1986/01/01
Date of Entry
1974/11/19
Revision Date
2016/05/27
Aromatase Preferred
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