MeSH Browser

MeSH Heading: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Tree Number(s): D08.244.453.499.500; D08.244.453.915.400; D08.811.682.690.708.170.493.500; D08.811.682.690.708.170.915.400; D12.776.422.220.453.499.500; D12.776.422.220.453.915.400
Unique ID: D015090
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015090
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Entry Term(s): 25-Hydroxycholecalciferol 1-Hydroxylase; 25-Hydroxycholecalciferol-1-Hydroxylase; 25-Hydroxyergocalciferol 1-alpha-Hydroxylase; 25-Hydroxyvitamin D 1-alpha-Hydroxylase; 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase; 25-Hydroxyvitamin D2 1-hydroxylase; CYP27B1; Calcidiol 1-Monooxygenase; Cytochrome P-450 CYP27B1
Registry Number: EC 1.14.15.18
CAS Type 1 Name: Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
Previous Indexing: Hydroxycholecalciferols (1973-1974); Steroid Hydroxylases (1973-1974)
Public MeSH Note: 2003; see 25-HYDROXYCHOLECALCIFEROL 1-HYDROXYLASE 1991-2002, see STEROID HYDROXYLASES 1975-1990; 25-HYDROXYVITAMIN D2 1-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1976-2002
History Note: 2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2019/04/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 27 [D08.244.453.499]
      - 25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.244.453.499.500]
      - Cholestanetriol 26-Monooxygenase [D08.244.453.499.750]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 27 [D08.811.682.690.708.170.493]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.493.500]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.493.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 27 [D12.776.422.220.453.499]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.499.500]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.499.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

25-Hydroxyvitamin D3 1-alpha-Hydroxylase Preferred

Concept UI: M0023210
Registry Number: EC 1.14.15.18
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Terms: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Preferred Term
Term UI T486666
Date03/20/2002
LexicalTag NON
ThesaurusID NLM (2003); 25-Hydroxycholecalciferol 1-Hydroxylase
Term UI T044048
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Calcidiol 1-Monooxygenase
Term UI T044049
Date11/25/1988
LexicalTag NON
ThesaurusID NLM (1988); 25-Hydroxyvitamin D 1-alpha-Hydroxylase
Term UI T498113
Date06/12/2002
LexicalTag NON
ThesaurusID NLM (2003); 25-Hydroxyvitamin D2 1-hydroxylase
Term UI T111778
LexicalTag NON
ThesaurusID NLM (2003); CYP27B1
Term UI T403219
Date12/20/1999
LexicalTag NON
ThesaurusID NLM (2001); Cytochrome P-450 CYP27B1
Term UI T403220
Date12/20/1999
LexicalTag NON
ThesaurusID NLM (2001); 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
Term UI T498112
Date06/12/2002
LexicalTag NON
ThesaurusID NLM (2003); 25-Hydroxycholecalciferol-1-Hydroxylase
Term UI T044047
Date05/23/1979
LexicalTag NON
ThesaurusID UNK (19XX); 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
Term UI T044050
Date10/12/1999
LexicalTag NON
ThesaurusID UNK (19XX)

25-Hydroxyvitamin D3 1-alpha-Hydroxylase MeSH Descriptor Data 2023