- Concept UI
- M0023210
- Registry Numbers
- EC 1.14.15.18
- Scope Note
- A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
- Terms
-
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Preferred Term
Term UI
T486666
Date03/20/2002
LexicalTag
NON
ThesaurusID
NLM (2003)
-
25-Hydroxycholecalciferol-1-Hydroxylase
Term UI
T044047
Date05/23/1979
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
25-Hydroxycholecalciferol 1-Hydroxylase
Term UI
T044048
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1975)
-
Calcidiol 1-Monooxygenase
Term UI
T044049
Date11/25/1988
LexicalTag
NON
ThesaurusID
NLM (1988)
-
25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
Term UI
T044050
Date10/12/1999
LexicalTag
NON
ThesaurusID
UNK (19XX)
-
25-Hydroxyvitamin D2 1-hydroxylase
Term UI
T111778
Date01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2003)
-
CYP27B1
Term UI
T403219
Date12/20/1999
LexicalTag
NON
ThesaurusID
NLM (2001)
-
Cytochrome P-450 CYP27B1
Term UI
T403220
Date12/20/1999
LexicalTag
NON
ThesaurusID
NLM (2001)
-
25-Hydroxyergocalciferol 1-alpha-Hydroxylase
Term UI
T498112
Date06/12/2002
LexicalTag
NON
ThesaurusID
NLM (2003)
-
25-Hydroxyvitamin D 1-alpha-Hydroxylase
Term UI
T498113
Date06/12/2002
LexicalTag
NON
ThesaurusID
NLM (2003)