MeSH Browser

MeSH Heading: Steroid 16-alpha-Hydroxylase
Tree Number(s): D08.244.453.915.737; D08.811.682.690.708.170.915.737; D12.776.422.220.453.915.737
Unique ID: D039181
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039181
Scope Note: A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.
Entry Term(s): 16-alpha Hydroxylase; 16alpha-Hydroxylase; Cytochrome P-450(16 alpha); Estradiol 16-alpha Hydroxylase; Estrogen 16-alpha Hydroxylase; Estrone 16-alpha Hydroxylase; Estrone-3-sulfate 16-alpha Hydroxylase; Progesterone 16 alpha-Hydroxylase; Progesterone 16-alpha-Hydroxylase; Progesterone-16-alpha-Hydroxylase; Steroid 16alpha-Hydroxylase; Testosterone 16-alpha Hydroxylase; Testosterone 16alpha Hydroxylase
Previous Indexing: Hydroxylases (1966-2002)
Public MeSH Note: 2003; PROGESTERONE 16 ALPHA-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1977-2002
History Note: 2003; use PROGESTERONE 16 ALPHA-HYDROXYLASE (NM) 1977-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/18
Revision Date: 2015/06/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Steroid 16-alpha-Hydroxylase Preferred

Concept UI: M0418489
Scope Note: A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spectrum of steroids, fatty acids, and xenobiotics in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme is encoded by a number of genes from several CYP2 subfamilies.
Terms: Steroid 16-alpha-Hydroxylase Preferred Term
Term UI T487200
Date03/25/2002
LexicalTag NON
ThesaurusID NLM (2003); 16-alpha Hydroxylase
Term UI T103487
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); 16alpha-Hydroxylase
Term UI T103488
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Estrogen 16-alpha Hydroxylase
Term UI T103508
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Estrone 16-alpha Hydroxylase
Term UI T103509
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Estrone-3-sulfate 16-alpha Hydroxylase
Term UI T103510
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Steroid 16alpha-Hydroxylase
Term UI T103511
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Estradiol 16-alpha Hydroxylase
Term UI T103512
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Progesterone-16-alpha-Hydroxylase
Term UI T108481
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Progesterone 16 alpha-Hydroxylase
Term UI T108482
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Testosterone 16-alpha Hydroxylase
Term UI T109221
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Cytochrome P-450(16 alpha)
Term UI T487201
Date03/25/2002
LexicalTag NON
ThesaurusID NLM (2003); Testosterone 16alpha Hydroxylase
Term UI T487380
Date03/26/2002
LexicalTag NON
ThesaurusID NLM (2003); Progesterone 16-alpha-Hydroxylase
Term UI T504442
Date07/17/2002
LexicalTag NON
ThesaurusID NLM (2003)

Steroid 16-alpha-Hydroxylase MeSH Descriptor Data 2025