MeSH Browser

MeSH Heading: Steroid 17-alpha-Hydroxylase
Tree Number(s): D08.244.453.487.500; D08.244.453.915.748; D08.811.682.690.708.170.444.500; D08.811.682.690.708.170.915.748; D12.776.422.220.453.487.500; D12.776.422.220.453.915.748
Unique ID: D013254
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013254
Scope Note: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Entry Term(s): 17 alpha-Hydroxylase; 17 alpha-Hydroxylase Cytochrome P-450; 17 alpha-Hydroxyprogesterone Aldolase; 17,20-Desmolase; 17,20-Lyase; CYP17; Cytochrome P-450(17 alpha); Cytochrome P-450(17-alpha); Cytochrome P450(17 alpha); Hydroxyprogesterone Aldolase; P450(c17); Steroid 17 alpha-Hydroxylase; Steroid 17 alpha-Monooxygenase; Steroid 17-Hydroxylase; Steroid 17-Monooxygenase; Steroid-17-Hydroxylase
Registry Number: EC 1.14.14.19
Related Numbers: 62213-24-5; 9029-67-8
CAS Type 1 Name: Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
Previous Indexing: Steroid Hydroxylases (1973-1977)
See Also: Adrenal Hyperplasia, Congenital
Public MeSH Note: 2003; see STEROID 17 ALPHA-MONOOXYGENASE 1997-2002, see STEROID 17-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990; for STEROID-17-HYDROXYLASE see STEROID HYDROXYLASES 1978-1989; for 17,20-LYASE see 17 ALPHA-HYDROXYPROGESTERONE ALDOLASE 1996-1997
History Note: 2003 (1978)
Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2016/06/01

Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 17 [D08.244.453.487]
      - Steroid 17-alpha-Hydroxylase [D08.244.453.487.500]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 17 [D08.811.682.690.708.170.444]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.444.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 17 [D12.776.422.220.453.487]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.487.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Steroid 17-alpha-Hydroxylase Preferred

Concept UI: M0020523
Registry Number: EC 1.14.14.19
Related Numbers: 62213-24-5; 9029-67-8
Scope Note: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Terms: Steroid 17-alpha-Hydroxylase Preferred Term
Term UI T494562
Date05/20/2002
LexicalTag NON
ThesaurusID NLM (2003); Steroid 17 alpha-Hydroxylase
Term UI T038952
Date12/06/1982
LexicalTag NON
ThesaurusID UNK (19XX); Steroid-17-Hydroxylase
Term UI T038953
Date11/07/1989
LexicalTag NON
ThesaurusID NLM (1990); Steroid 17-Hydroxylase
Term UI T038954
Date03/01/1996
LexicalTag NON
ThesaurusID NLM (1997); Steroid 17-Monooxygenase
Term UI T038955
Date04/05/1977
LexicalTag NON
ThesaurusID UNK (19XX); 17,20-Desmolase
Term UI T038956
Date12/13/1996
LexicalTag NON
ThesaurusID NLM (1998); 17,20-Lyase
Term UI T038957
Date12/13/1996
LexicalTag NON
ThesaurusID NLM (1998); Cytochrome P450(17 alpha)
Term UI T038958
Date03/01/1996
LexicalTag NON
ThesaurusID NLM (1997); Steroid 17 alpha-Monooxygenase
Term UI T038959
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); CYP17
Term UI T038960
Date12/13/1996
LexicalTag ABB
ThesaurusID NLM (1998); 17 alpha-Hydroxylase
Term UI T038961
Date12/13/1996
LexicalTag NON
ThesaurusID NLM (1998); P450(c17)
Term UI T038962
Date12/13/1996
LexicalTag NON
ThesaurusID NLM (1998); Cytochrome P-450(17-alpha)
Term UI T108454
LexicalTag NON
ThesaurusID NLM (2003); 17 alpha-Hydroxylase Cytochrome P-450
Term UI T038950
Date10/11/1988
LexicalTag NON
ThesaurusID UNK (19XX); Cytochrome P-450(17 alpha)
Term UI T038951
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX)

17 alpha-Hydroxyprogesterone Aldolase Narrower

Steroid 17-alpha-Hydroxylase MeSH Descriptor Data 2023