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Sterol 14-Demethylase MeSH Descriptor Data 2023


MeSH Heading
Sterol 14-Demethylase
Tree Number(s)
D08.244.453.878.500
D08.244.453.915.880
D08.811.682.690.708.170.499.500
D08.811.682.690.708.170.915.880
D12.776.422.220.453.878.500
D12.776.422.220.453.915.880
Unique ID
D058886
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D058886
Scope Note
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Entry Term(s)
CYP51 Cytochrome P-450
Cytochrome P-450 CYP51
Eburicol 14 alpha-Demethylase
Eburicol 14alpha-Demethylase
Lanosterol 14 alpha-Demethylase
Obtusifoliol 14alpha-Demethylase
Sterol 14-Demethylases
Sterol 14-alpha-Demethylase
Registry Number
EC 1.14.14.154
Public MeSH Note
2011; STEROL 14-DEMETHYLASE was indexed under CYTOCHROME P-450 ENZYME SYSTEM 2009-2010, under OXIDOREDUCTASES 1978-2008, & under LANOSTEROL 1976-1982
History Note
2011
Entry Combination
antagonists & inhibitors:14-alpha Demethylase Inhibitors
Date Established
2011/01/01
Date of Entry
2010/06/25
Revision Date
2019/07/05
Sterol 14-Demethylase Preferred
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