MeSH Browser

MeSH Heading: Cholesterol Side-Chain Cleavage Enzyme
Tree Number(s): D08.244.453.484.250; D08.244.453.915.212; D08.811.682.690.708.170.425.250; D08.811.682.690.708.170.915.212; D12.776.422.220.453.484.250; D12.776.422.220.453.915.212
Unique ID: D002786
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002786
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
Entry Term(s): 20,22-Desmolase; CYP 11A1; CYP11A1; Cholesterol Desmolase; Cholesterol Monooxygenase (Side-Chain-Cleaving); Cytochrome P-450 CYP11A1; Cytochrome P-450(scc); Cytochrome P450 11A1; Cytochrome P450scc
CAS Type 1 Name: Cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Previous Indexing: Cholesterol (1971-1974); Multienzyme Complexes (1973-1974); Oxidoreductases (1971-1974)
Public MeSH Note: 2003; see CHOLESTEROL MONOOXYGENASE 1997-2002, see CHOLESTEROL DESMOLASE 1988-1996, see OXIDOREDUCTASES 1975-1987
History Note: 2003 (1975)
Date Established: 1988/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 11 [D08.244.453.484]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 11 [D08.811.682.690.708.170.425]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.425.250]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.425.500]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.425.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 11 [D12.776.422.220.453.484]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.484.250]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.484.500]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.484.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Cholesterol Side-Chain Cleavage Enzyme Preferred

Concept UI: M0004271
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
Terms: Cholesterol Side-Chain Cleavage Enzyme Preferred Term
Term UI T008086
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Cytochrome P450 11A1
Term UI T008090
Date02/23/1996
LexicalTag NON
ThesaurusID NLM (1997); Cytochrome P-450 CYP11A1
Term UI T008091
Date02/08/1996
LexicalTag NON
ThesaurusID NLM (1997); Cholesterol Monooxygenase (Side-Chain-Cleaving)
Term UI T008092
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); CYP11A1
Term UI T008093
Date02/08/1996
LexicalTag ABB
ThesaurusID NLM (1997); 20,22-Desmolase
Term UI T008084
Date10/09/1986
LexicalTag NON
ThesaurusID UNK (19XX); Cholesterol Desmolase
Term UI T008085
Date02/08/1996
LexicalTag NON
ThesaurusID NLM (1997); Cytochrome P-450(scc)
Term UI T008087
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); CYP 11A1
Term UI T008089
Date02/08/1996
LexicalTag ABB
ThesaurusID NLM (1997); Cytochrome P450scc
Term UI T008088
Date12/08/1987
LexicalTag NON
ThesaurusID UNK (19XX)

Cholesterol Side-Chain Cleavage Enzyme MeSH Descriptor Data 2025