MeSH Browser

MeSH Heading: Steroid 21-Hydroxylase
Tree Number(s): D08.244.453.493.500; D08.244.453.915.760; D08.811.682.690.708.170.463.500; D08.811.682.690.708.170.915.760; D12.776.422.220.453.493.500; D12.776.422.220.453.915.760
Unique ID: D013255
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013255
Scope Note: An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Entry Term(s): 21-Hydroxylase; Cytochrome P-450 21-Hydroxylase; Cytochrome P-450 CYP21; Cytochrome P-450 c21; Cytochrome P-450(c-21); Cytochrome P450c21; Progesterone 21-Hydroxylase; Steroid 21-Monooxygenase; Steroid-21-Hydroxylase
CAS Type 1 Name: Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
Previous Indexing: Steroid Hydroxylases (1973-1977)
Public MeSH Note: 2003; see STE see STEROID 21-MONOOXYGENASE 1997-2002, see STEROID 21-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 21-MONOOXYGENASE see STEROID 21-HYDROXYLASE 1978-1996; CYTOCHROME P-450 C21 was indexed under STEROID 21-HYDROXYLASE 2004 & under CYTOCHROME P-450 ENZYME SYSTEM 1996-2003
History Note: 2003 (1978)
Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2016/06/01

Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 21 [D08.244.453.493]
      - Steroid 21-Hydroxylase [D08.244.453.493.500]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 21 [D08.811.682.690.708.170.463]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.463.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 21 [D12.776.422.220.453.493]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.493.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Steroid 21-Hydroxylase Preferred

Concept UI: M0020524
Scope Note: An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Terms: Steroid 21-Hydroxylase Preferred Term
Term UI T038969
Date06/13/1996
LexicalTag NON
ThesaurusID NLM (1997); Cytochrome P-450 21-Hydroxylase
Term UI T038965
Date04/23/1988
LexicalTag NON
ThesaurusID UNK (19XX); Cytochrome P-450(c-21)
Term UI T038966
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); Progesterone 21-Hydroxylase
Term UI T038967
Date08/25/1980
LexicalTag NON
ThesaurusID UNK (19XX); Steroid-21-Hydroxylase
Term UI T038968
Date11/07/1989
LexicalTag NON
ThesaurusID NLM (1990); Steroid 21-Monooxygenase
Term UI T038970
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Cytochrome P450c21
Term UI T290725
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Cytochrome P-450 c21
Term UI T290726
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); 21-Hydroxylase
Term UI T038964
Date07/28/1981
LexicalTag NON
ThesaurusID UNK (19XX); Cytochrome P-450 CYP21
Term UI T486684
Date03/21/2002
LexicalTag NON
ThesaurusID NLM (2003)

Steroid 21-Hydroxylase MeSH Descriptor Data 2025