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Steroid 21-Hydroxylase MeSH Descriptor Data 2022


MeSH Heading
Steroid 21-Hydroxylase
Tree Number(s)
D08.244.453.493.500
D08.244.453.915.760
D08.811.682.690.708.170.463.500
D08.811.682.690.708.170.915.760
D12.776.422.220.453.493.500
D12.776.422.220.453.915.760
Unique ID
D013255
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013255
Scope Note
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Entry Term(s)
21-Hydroxylase
Cytochrome P-450 21-Hydroxylase
Cytochrome P-450 CYP21
Cytochrome P-450 c21
Cytochrome P-450(c-21)
Cytochrome P450c21
Progesterone 21-Hydroxylase
Steroid 21-Monooxygenase
Steroid-21-Hydroxylase
Registry Number
EC 1.14.14.16
CAS Type 1 Name
Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
Previous Indexing
Steroid Hydroxylases (1973-1977)
Public MeSH Note
2003; see STE see STEROID 21-MONOOXYGENASE 1997-2002, see STEROID 21-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 21-MONOOXYGENASE see STEROID 21-HYDROXYLASE 1978-1996; CYTOCHROME P-450 C21 was indexed under STEROID 21-HYDROXYLASE 2004 & under CYTOCHROME P-450 ENZYME SYSTEM 1996-2003
History Note
2003 (1978)
Entry Combination
deficiency:Adrenal Hyperplasia, Congenital
Date Established
1991/01/01
Date of Entry
1977/04/15
Revision Date
2016/06/01
Steroid 21-Hydroxylase Preferred
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