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Cholesterol 7-alpha-Hydroxylase MeSH Descriptor Data 2022


MeSH Heading
Cholesterol 7-alpha-Hydroxylase
Tree Number(s)
D08.244.453.890.500
D08.244.453.915.200
D08.811.682.690.708.170.890.500
D08.811.682.690.708.170.915.200
D12.776.422.220.453.890.500
D12.776.422.220.453.915.200
Unique ID
D002790
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002790
Scope Note
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Entry Term(s)
CYP 7
CYP 7A
CYP7
CYP7A
Cholesterol 7-alpha-Monooxygenase
Cholesterol 7alpha-Hydroxylase
Cholesterol-7-Hydroxylase
Cytochrome P-450 CYP7
Cytochrome P450 7
Registry Number
EC 1.14.14.23
Related Numbers
9037-53-0
CAS Type 1 Name
Cholesterol,NADPH:oxygen oxidoreductase (7 alpha-hydroxylating)
NLM Classification #
QU 140
Previous Indexing
Cholesterol (1974)
Steroid Hydroxylases (1974)
Public MeSH Note
2003; see CHOLESTEROL 7 ALPHA-MONOOXYGENASE 1997-2002, see CHOLESTEROL-7-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1975-1990
History Note
2003 (1975)
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2016/06/01
Cholesterol 7-alpha-Hydroxylase Preferred
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