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Cytochrome P-450 CYP11B2 MeSH Descriptor Data 2022


MeSH Heading
Cytochrome P-450 CYP11B2
Tree Number(s)
D08.244.453.484.500
D08.244.453.915.050
D08.811.682.690.708.170.425.500
D08.811.682.690.708.170.915.050
D12.776.422.220.453.484.500
D12.776.422.220.453.915.050
Unique ID
D019405
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019405
Annotation
/antag: coordinate with CYTOCHROME P-450 ENZYME INHIBITORS
Scope Note
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Entry Term(s)
Aldosterone Synthase
Aldosterone Synthase Cytochrome P-450
Aldosynthase
CYP 11B2
CYP11B2
Corticosterone 18-hydroxylase
Corticosterone 18-monooxygenase
Cytochrome P-450c11AS
Cytochrome P450 11B2
Cytochrome P450Aldo
P450c11AS
Steroid 18-Hydroxylase
Registry Number
EC 1.14.15.4
Related Numbers
37256-75-0
EC 1.14.15.4
Previous Indexing
Cytochrome P-450 (1984-1996)
Desoxycorticosterone (1979-1982)
Steroid 11 beta-Monooxygenase (1994-1996)
Steroid Hydroxylases (1979-1993)
Public MeSH Note
2015; see ALDOSTERONE SYNTHASE 2003-2014; see CYTOCHROME P-450 CYP11B2 1977-2002; for STEROID 18-HYDROXYLASE see CYTOCHROME P-450 1984-1996, see STEROID 11-HYDROXYLASE 1994-1996, see STEROID HYDROXYLASES 1979-1993, & see DESOXYCORTICOSTERONE 1979-1982
History Note
2015 (1979)
Date Established
1997/01/01
Date of Entry
1996/06/24
Revision Date
2020/06/22
Cytochrome P-450 CYP11B2 Preferred
Corticosterone 18-monooxygenase Related
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